Abstract: Objective To explore the value and risk factors of tumor deposit in prognosis of advanced gastric cancer . Methods Clinicopathological characteristics and follow-up date of 183 cases with advanced gastric cancer undergoing radical gastrectomy from March 2013 to January 2017 in Xuzhou Medical University Hospital were analyzed retrospectively. The positive rate of tumor deposit was statistically analyzed. Association of tumor deposit with clinicopathological characteristics and the risk factors. Prognostic difference between positive tumor deposit group and negative tumor deposit group was examined. Results Univariate analysis showed that TNM staging （P＜0.001），vessel invasion （P=0.018）and lymph node metastasis（P＜0.001）were closely associated with tumor deposit. Logistic multivariate analysis showed that TNM staging (P=0.010) was an independent risk factor for positive tumor deposit. The results of univariate analysis indicated that tumor differentiation (P=0.009), tumor size (P=0.002), the number of tumor deposits (P<0.001), invasion depth (P<0.001), lymph node metastasis (P<0.001), TNM staging (P<0.001), vessel invasion (P=0.001), neural invasion (P=0.046), preoperative CEA level (P<0.001) and postoperative chemotherapy (P=0.001) were found to be significantly associated with the prognosis of advanced gastric cancer. Multivariate analysis showed that the number of tumor deposits (P<0.001), lymph node metastasis (P=0.011), postoperative chemotherapy (P<0.001), vessel invasion (P=0.021) and preoperative CEA level (P=0.003) were independent risk factors for the prognosis of advanced gastric cancer. Conclusions The number tumor deposits may be an independent risk factor for the prognosis of advanced gastric cancer. The TNM staging is late, the positive of cancer nodules may be large and the prognosis is worse.