[1]陶思冥.频繁急性加重表型COPD患者外周血Th1、Th2和Th17、Treg差异表达研究[J].徐州医科大学学报,2019,39(08):576-579.
 [J].Journal of Xuzhou Medical University,2019,39(08):576-579.
点击复制

频繁急性加重表型COPD患者外周血Th1、Th2和Th17、Treg差异表达研究()
分享到:

《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年08期
页码:
576-579
栏目:
出版日期:
2019-08-25

文章信息/Info

作者:
陶思冥
文献标志码:
A
摘要:
目的 探讨频繁急性加重表型COPD患者外周血Th1、Th2和Th17、Treg差异表达变化情况。方法 纳入频繁急性加重表型COPD患者36例,非频繁急性加重患者37例,健康组患者14例,完善每位COPD患者的临床资料,用流式细胞技术检测患者外周血Th1、Th2、Th17、Treg水平,分析不同表型之间的免疫细胞的表达水平情况。结果 频繁急性加重表型、非频繁急性加重表型COPD患者在Th1、Th2、Th17表达无差异(p>0.05),但Treg比值有明显差异(p<0.05),不同表型之间年急性加重次数和CAT评分存在显著差异(p<0.05)。结论 在频繁急性加重表型COPD发病机制中,Treg介导的抑制炎症反应可能占主导地位, CAT评分可作为判别频繁急性加重表型的指标之一。
Abstract:
Objective To investigate the differential expression of Th1, Th2, Th17 and Treg in peripheral blood of patients with frequent acute exacerbation of phenotype. Methods Thirty-six patients with frequent acute phenotype of COPD, thirty-seven patients with non-frequent acute exacerbation, fourteen patients with healthy patients were included in the study. and improve the clinical data of each COPD patient. and peripheral blood Th1 and Th2 were detected by flow cytometry. Levels of Th17 and Treg were analyzed for the expression level of immune cells between different phenotypes. Results There was no difference in the expression of Th1, Th2, Th17 in patients with frequent acute exacerbation phenotype and infrequently exacerbated phenotype COPD (p>0.05), but the Treg ratio was significantly different (p<0.05). There was a significant difference from the number of years of acute exacerbation and CAT score (p<0.05). Conclusion In the pathogenesis of frequent acute exacerbation of phenotypic COPD, Treg-mediated inhibition of inflammatory response may be dominant, and CAT score can be used as one of the indicators to discriminate the frequent acute exacerbation phenotype.
更新日期/Last Update: 2019-09-18