Abstract:
Objective To investigate the differential expression of Th1, Th2, Th17 and Treg in peripheral blood of patients with frequent acute exacerbation of phenotype. Methods Thirty-six patients with frequent acute phenotype of COPD, thirty-seven patients with non-frequent acute exacerbation, fourteen patients with healthy patients were included in the study. and improve the clinical data of each COPD patient. and peripheral blood Th1 and Th2 were detected by flow cytometry. Levels of Th17 and Treg were analyzed for the expression level of immune cells between different phenotypes. Results There was no difference in the expression of Th1, Th2, Th17 in patients with frequent acute exacerbation phenotype and infrequently exacerbated phenotype COPD (p>0.05), but the Treg ratio was significantly different (p<0.05). There was a significant difference from the number of years of acute exacerbation and CAT score (p<0.05). Conclusion In the pathogenesis of frequent acute exacerbation of phenotypic COPD, Treg-mediated inhibition of inflammatory response may be dominant, and CAT score can be used as one of the indicators to discriminate the frequent acute exacerbation phenotype.