[1]郭宁宁,付冬霞,孙青风.血清Hcy、hs-CRP及IL8水平与2型糖尿病合并抑郁症 患者疗效的相关研究[J].徐州医科大学学报,2019,39(08):571-575.
 Relationship between Serum Hcy,hs-CRP and IL8 Levels and the Outcome of Type 2 Diabetes Combined with Depression[J].Journal of Xuzhou Medical University,2019,39(08):571-575.
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血清Hcy、hs-CRP及IL8水平与2型糖尿病合并抑郁症 患者疗效的相关研究()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年08期
页码:
571-575
栏目:
出版日期:
2019-08-25

文章信息/Info

Title:
Relationship between Serum Hcy,hs-CRP and IL8 Levels and the Outcome of Type 2 Diabetes Combined with Depression
作者:
郭宁宁付冬霞孙青风
文献标志码:
A
摘要:
目的 本文旨在研究血清中Hcy(同型半胱氨酸)、hs-CRP(血清超敏C反应蛋白)及IL8(白介素8)的水平与2型糖尿病(T2DM)合并抑郁症患者疗效的相关性。方法 选取2015 年12月至 2017 年12 月收治入我院内分泌科确诊为T2DM合并抑郁症的患者110例作为研究对象。所有患者均采用常规降糖联合抗抑郁治疗。治疗后采用抑郁自评量表(se1f-rating depression sca1e,SDS)将患者分为优良组(n=55)和一般组(n=55)。比较两组患者一般临床资料,治疗前后的心理障碍程度和血糖变化情况。采用循环酶法测定两组患者血清Hcy水平,免疫比浊法测定hs-CRP水平,E1ISA法检测血清IL8水平。Pearson积矩相关系数分析患者疗效情况与三种血清标志物水平的相关性。结果 治疗后两组患者SDS和HAMD评分下降,有统计学意义(均P<0.05),SAS和HAMA评分变化无显著意义(均P>0.05)。治疗后优良组SDS和HAMD评分显著低于一般组(均P<0.05)。两组患者血糖水平指标经治疗后有不同程度下降(均P<0.05),但两组间差异无统计学意义(均P>0.05)。治疗后两组病例的各标志物水平较治疗前均明显降低,且优良组标志物水平明显低于一般组(均P < 0.05)。治疗组患者三种血清标志物与SDS评分均呈正相关(均P < 0.05);其中Hcy与患者抑郁程度变化的相关性最强(均P < 0.05)。结论 治疗后血清中Hcy、hs-CRP及IL8水平的高低与T2DM合并抑郁症患者的抑郁程度呈正相关,可能为改善T2DM合并抑郁症患者的疗效提供临床依据。
Abstract:
Objective To investigate the relationship between the serum levels of Hcy (homocysteine), hs-CRP (serum high-sensitivity C-reactive protein) and IL-8 (interleukin-8) and the efficacy of patients with type 2 diabetes mellitus (T2DM) complicated with depression. Methods 110 patients with T2DM and depression diagnosed in our hospital from December 2015 to December 2017 were enrolled as subjects. All patients were treated with conventional hypoglycemic therapy combined with antidepressant therapy. Patients were divided into excellent group (n=55) and general group (n=55) by treatment with se1f-rating depression sca1e (SDS). The general clinical data of the two groups of patients, the degree of psychological disorder and blood glucose changes before and after treatment were compared. Serum Hcy levels were measured by circulating enzymatic method, hs-CRP levels were determined by immunoturbidimetry, and serum IL8 levels were detected by E1ISA method. The Pearson product moment correlation coefficient was used to analyze the correlation between the patient’’s efficacy and the three serum markers. Results After treatment, the SDS and HAMD scores of the two groups were statistically significant (P<0.05), and there was no significant difference in SAS and HAMA scores (both P>0.05). After treatment, the SDS and HAMD scores of the excellent group were significantly lower than those of the general group (both P<0.05). The blood glucose levels of the two groups were decreased after treatment (P<0.05), but the difference between the two groups was not statistically significant (P>0.05). After treatment, the levels of each marker in the two groups were significantly lower than those before treatment, and the level of the excellent group was significantly lower than that in the general group (all P < 0.05). There were positive correlations between the three serum markers and SDS scores in the treatment group (all P < 0.05); Hcy was the strongest correlation with the change of depression (P < 0.05). Conclusions The level of serum Hcy, hs-CRP and IL8 levels after treatment was positively correlated with the degree of depression in patients with T2DM and depression, which may provide a clinical basis for improving the efficacy of patients with T2DM and depression.
更新日期/Last Update: 2019-09-18