[1]黄海涛.非诺贝特联合依折麦布治疗2型糖尿病并高脂血症对代谢指标、内皮功能的影响[J].徐州医科大学学报,2019,39(07):530-533.
 Effects of fenofibrate combined with ezramib on metabolic parameters and endothelial function in type 2 diabetes complicated with hyperlipidemia[J].Journal of Xuzhou Medical University,2019,39(07):530-533.
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非诺贝特联合依折麦布治疗2型糖尿病并高脂血症对代谢指标、内皮功能的影响()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年07期
页码:
530-533
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Effects of fenofibrate combined with ezramib on metabolic parameters and endothelial function in type 2 diabetes complicated with hyperlipidemia
作者:
黄海涛
文献标志码:
A
摘要:
目的:探讨非诺贝特联合依折麦布治疗2型糖尿病并高脂血症对代谢指标、内皮功能的影响。方法:收集2013年1月至2018年6月2型糖尿病并高脂血症患者120例,随机分为试验组和对照组,各60例。试验组给予非诺贝特联合依折麦布治疗,对照组仅给予依折麦布治疗,观察两组患者治疗后代谢指标及内皮功能变化。结果:试验组治疗有效率高于对照组,治疗后血清TC、TG、LDL-C等脂代谢指标,FPG,2hPG和餐后最高血糖等糖代谢指标及内皮功能指标PAI-1均低于对照组,而HDL-C和NO、ET-1均高于对照组,差异均有统计学意义(P<0.05)。结论:非诺贝特联合依折麦布治疗2型糖尿病并高脂血症具有良好的疗效,可有效改善患者代谢指标和内皮功能。
Abstract:
Objective: To investigate the effects of fenofibrate combined with ezromycin on metabolism and endothelial function in type 2 diabetes complicated with hyperlipidemia. Methods: 120 patients with type 2 diabetes and hyperlipidemia from January in our hospital from 2013 to June 2018 were randomly divided into experimental group and control group, 60 cases in each group. The experimental group was treated with fenofibrate combined with ezumab, while the control group was only treated with ezumab. The changes of metabolic index and endothelial function in the two groups were observed after treatment. Results: The effective rate of treatment in the experimental group was higher than that in the control group. After treatment, serum TC, TG, LDL-C, FPG, 2hPG, postprandial maximum blood glucose and PAI-1 were lower than those in the control group, while HDL-C, NO, ET-1 were higher than those in the control group (P < 0.05). Conclusion: Fenofibrate combined with Ezymib has a good effect in the treatment of type 2 diabetes complicated with hyperlipidemia, and can effectively improve the metabolic index and endothelial function.
更新日期/Last Update: 2019-07-11