[1]程熳云,时宏娟,花放.重症肌无力52例临床分析并文献复习[J].徐州医科大学学报,2019,39(07):537-540.
 Myasthenia gravis-a clinical analysis of 52 cases and literature review[J].Journal of Xuzhou Medical University,2019,39(07):537-540.
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重症肌无力52例临床分析并文献复习()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年07期
页码:
537-540
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Myasthenia gravis-a clinical analysis of 52 cases and literature review
作者:
程熳云时宏娟花放
文献标志码:
A
摘要:
目的 探讨重症肌无力(MG)的临床特征、诊断。方法 回顾性分析徐州医科大学附属医院 神经内科于2015年1月至2018年7月收治的52例MG患者的临床资料。利用 SPSS19.0统计分析软件进行统计分析,检验水准为0.05。符合正态分布的计量资料采用均数±标准差表示,采用独立样本 t 检验;符合偏态分布的计量资料采用中位数(全距)表示,两组间比较数据采用秩和检验。计数资料采用频数(百分比)表示,两组间比较采用卡方检验。 结果 本组患者主要临床表现眼睑下垂、视物成双、声音嘶哑或吞咽困难、四肢无力、少见呼吸费力。新斯的明试验阳性率100%(52/52)。重复神经电刺激阳性率为 90.7%(39/43)。胸腺CT检查阳性率52%(26/50)。甲状腺功能阳性率28.9%(13/45),男性异常率10.5%(2/19),女性异常率42.3%(11/26)。结论 本组患者女性较多,多以眼肌症状首发,I型和IIB型较为常见,新斯的明试验和重复电刺激阳性率较高,女性常伴有胸腺、甲状腺异常,自身抗体检测有助于指导合理诊疗及评估预后。
Abstract:
Objective To investigate the clinical features, diagnosis, of myasthenia gravis (MG).Methods The clinical data of 52 patients with MG admitted from January 2015 to July 2018 in Department of Neurology, affiliated Hospital of Xuzhou Medical University were retrospectively analyzed..Using SPSS19.0 statistical analysis software for statistical analysis, the test level is 0. 05.The clinical data of a case of MOG antibody disease with epilepsy onset who were admitted into the Affiliated Hospital of Xuzhou Medical University in July 2018 were retrospectively analyzed. Results The main clinical manifestations of ocular muscle prolapse, diplopia, hoarseness or dysphagia, limb weakness, breathing effort.Positive rate of neostigmine test 100% (52/52).The positive rate of repetitive nerve stimulation was 90.7% (39/43).The positive rate of thymus CT was 52% (26/50).The positive rate of thyroid function was 28.9% (13/45), the abnormal rate of male was 10.5% (2/19), the abnormal rate of female was 42.3% (11/ 26).Conclusions There were more women in this group, most of whom were ophthalmic symptoms, type I and IIB were more common, the positive rate of neostigmine test and repetitive electrical stimulation was higher, and women were often accompanied with thymus and thyroid abnormalities. The detection of autoantibodies is helpful to guide rational diagnosis and treatment and to evaluate prognosis
更新日期/Last Update: 2019-07-11