[1]高胜国,樊瑞智,梁勇,等.手术前后中性粒细胞淋巴细胞比值变化与胃肠间质瘤预后的关系[J].徐州医科大学学报,2019,39(07):487-492.
 Relationship between preoperative and postoperative changes of neutrophil-to-lymphocyte ratio and the prognosis of gastrointestinal stromal tumor[J].Journal of Xuzhou Medical University,2019,39(07):487-492.
点击复制

手术前后中性粒细胞淋巴细胞比值变化与胃肠间质瘤预后的关系()
分享到:

《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年07期
页码:
487-492
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Relationship between preoperative and postoperative changes of neutrophil-to-lymphocyte ratio and the prognosis of gastrointestinal stromal tumor
作者:
高胜国樊瑞智梁勇宋虎许腾徐溢新徐为
文献标志码:
A
摘要:
摘要: 目的 探讨手术前后中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio ,NLR)的变化与胃肠间质瘤患者预后的关系。方法 回顾性分析手术治疗的228例胃肠间质瘤患者的临床及病理资料,根据手术前后NLR的变化分为两组。分析手术前后NLR变化与胃肠间质瘤患者的临床病理特征及无瘤生存的关系。 结果 术后NLR升高组和NLR降低组的患者在性别、 年龄、 肿瘤位置、术后是否伊马替尼辅助治疗方面相比,差异均无统计学意义(P>0.05),而在肿瘤大小、危险度、核分裂象、Ki-67增殖指数、术前NLR方面比较,差异有统计学意义(P<0.05)。单因素分析提示以下因素直接影响患者的无瘤生存期:肿瘤大小、危险度、Ki-67增殖指数、术后是否伊马替尼辅助治疗、术前NLR、术前术后NLR变化。Cox多因素风险回归显示,肿瘤大小、肿瘤危险度、术前NLR、术前术后NLR变化是影响患者无瘤生存期的独立因素。结论 手术前后NLR变化是影响胃肠间质瘤预后的独立因素,有望成为预测胃肠间质瘤预后的一种有效评估新指标。
Abstract:
Abstract: Objective To investigate the relationship between preoperative and postoperative changes of neutrophil-lymphocyte ratio(NLR) and prognosis of gastrointestinal stromal tumor. Method The clinical and pathological data of 228 patients with gastrointestinal stromal tumors were analyzed retrospectively. They were divided into two groups according to the preoperative and postoperative changes of NLR. The relationship between preoperative and postoperative NLR changes and clinicopathological features and disease-free survival of patients with gastrointestinal stromal tumors were analyzed. Results There were no significant differences in gender, age, tumor location, and adjuvant treatment with imatinib after surgery in the NLR-increased group and the NLR-decreased group (P>0.05). The differences in risk, mitotic figures, Ki-67 proliferation index, and preoperative NLR were statistically significant (P<0.05). Univariate analysis suggested that the following factors directly affected the patient’’’’’’’’’’’’’’’’s disease-free survival : tumor size, risk, Ki-67 proliferation index, postoperative imatinib adjuvant therapy, preoperative NLR, preoperative and postoperative NLR changes. Cox multivariate risk regression showed that tumor size, tumor risk, preoperative NLR, preoperative and preoperative NLR changes were independent factors affecting disease-free survival in patients. Conclusion Preoperative and postoperative changes in NLR are independent factors affecting the prognosis of gastrointestinal stromal tumor, and it is expected to be an effective evaluation index for predicting the prognosis of gastrointestinal stromal tumor.
更新日期/Last Update: 2019-07-11