[1]钱宏波.ICCFC诊断艾滋病合并肺结核的临床价值[J].徐州医科大学学报,2019,39(08):617-620.
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ICCFC诊断艾滋病合并肺结核的临床价值()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年08期
页码:
617-620
栏目:
出版日期:
2019-08-25

文章信息/Info

Title:
Clinical value of ICCFC in diagnosing AIDS complicated with pulmonary tuberculosis
作者:
钱宏波
文献标志码:
A
摘要:
目的:探析ICCFC诊断艾滋病合并肺结核的临床价值,为疾病早期诊断和治疗提供依据。 方法 选取2017年8月-2018年5月在我院诊治的38例艾滋病合并肺结核患者(感染组),44例单纯艾滋病患者(高危组)以及20例健康人群(对照组),采用ICCFC法测外周血中因被结核菌抗原刺激而分泌IFN-γ的特异性T细胞的比例;并与ELISATB-IGRA检测结果进行对比,通过ROC曲线分析诊断的临床价值。 结果 数据分析显示,ICCFC法诊断的灵敏度(92.1%)、特异度(96.9%)以及约登系数0.889都优于与ELISATB-IGRA检测(灵敏度71.1%、特异度89.1%、约登系数0.602)。ICCFC法ROC曲线下面积(AUG)0.842,95%CI:0.763~0.921,TB-IGRA检测 AUG 0.780,95%CI:0.687~0.872。 结论 ICCFC法诊断艾滋病合并肺结核的敏感度和特异度较高,有较高的诊断效能。
Abstract:
Objective To analyze the clinical value of ICCFC in diagnosing AIDS complicated with pulmonary tuberculosis, and to provide evidence for early diagnosis and treatment of diseases. Methods 38 patients with AIDS complicated with pulmonary tuberculosis (infected group) were treated in our hospital from July 2017 to May 2018, 44 patients with AIDS alone (high risk group) and 20 healthy people (control group) were tested by ICCFC method. The proportion of specific T cells secreting IFN-γ in peripheral blood due to stimulation by tuberculosis antigen; and compared with the ELISA TB-IGRA test results, the clinical value of the diagnosis was analyzed by ROC curve. Results Analysis of the data showed that the sensitivity ( 92.1%), specificity (96.9%) and the Yoden coefficient of 0.889 of the ICCFC method were better than those of the ELISA TB-IGRA (sensitivity 71.1%, specificity 89.1%, approximate coefficient 0.602). . ICCFC method under the ROC curve area (AUG) 0.842, 95% CI: 0.763~0.921, TB-IGRA detection AUG 0.780, 95% CI: 0.687~0.872. Conclusion The ICCFC method has higher sensitivity and specificity for diagnosing AIDS complicated with pulmonary tuberculosis, and has higher diagnostic efficacy.
更新日期/Last Update: 2019-09-18