Abstract:
Objective To investigate the correlation between CRP/Alb ratio (CAR) and clinicopathological features of small cell lung cancer (SCLC) and its prognostic value.Methods The CRP and Alb before receiving the treatment of 80 healthy controls and SCLC patients in our center were retrospectively analyzed. CAR values were calculated. The correlation between CAR values and clinicopathological characteristics of SCLC patients was analyzed by chi-square test. The relationship between CAR and prognosis of SCLC was analyzed by Kaplan-Meier method and COX regression model.Result The serum CRP of SCLC patients (6.95 ± 3.21) mg/L was higher than that of healthy control group (3.13 ±1.69) mg/L, with statistical difference (P < 0.05). Alb level (35.71 ± 6.68) g/L was lower than that of healthy control group (45.63 ± 5.78), the difference was statistically significant (P < 0.05). The level of CAR (0.20 ±0.10) was higher than that of healthy control group (0.07 ± 0.04), with statistical difference (P < 0.05). Further analysis showed that CAR was positively correlated with lymph node metastasis and clinical stage (P < 0.05), but not with age, sex, smoking history and tumor size. Survival analysis revealed that patients with high expression of CAR had worse prognosis than those with low expression of CAR (P < 0.05). COX multivariate regression analysis demonstrated that the level of CAR could be used as an independent prognostic factor (P < 0.05). Conclusion CAR detection has the advantages of high efficiency, agility, economy and minimal trauma. The combined detection of CRP and Alb has an important application value in the clinical staging and prognosis of SCLC