[1]嵇桂娟.初始治疗前CRP/Alb比值与小细胞肺癌患者临床病理特征及预后的关系[J].徐州医科大学学报,2019,39(07):481-486.
 Relationship between CRP/Alb ratio before initial treatment and clinicopathological features and prognosis of patients with small cell lung cancer[J].Journal of Xuzhou Medical University,2019,39(07):481-486.
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初始治疗前CRP/Alb比值与小细胞肺癌患者临床病理特征及预后的关系()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年07期
页码:
481-486
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Relationship between CRP/Alb ratio before initial treatment and clinicopathological features and prognosis of patients with small cell lung cancer
作者:
嵇桂娟
文献标志码:
A
摘要:
目的 探讨初始治疗前CRP/Alb比值(CAR)与小细胞肺癌(small cell lung cancer,SCLC)临床病理特征相关性及其在预后中的价值。方法 回顾性分析本中心80例健康对照人群及SCLC患者的治疗前CRP、Alb值,计算CAR值,卡方检验分析CAR值与SCLC患者临床病理特征的相关性,Kaplan-Meier法及COX回归模型分析CAR与SCLC预后的关系。结果 治疗前SCLC患者血清CRP(6.95±3.21)mg/L高于健康对照组(3.13±1.69) mg/L ,具有统计学差异(P<0.05)。Alb水平(35.71±6.68)g/L低于健康对照组(45.63±5.78),差异具有统计学意义(P<0.05)。CAR水平(0.20±0.10)高于健康对照组(0.07±0.04),具有统计学差异(P<0.05)。进一步分析CAR值与淋巴结转移和临床分期呈正相关(P<0.05),与年龄、性别、吸烟史以及肿瘤大小无关。生存分析证实:相比较于CAR值低表达患者,CAR值高表达患者预后更差,具有统计学差异(P<0.05)。COX多因素回归分析证实,CAR高低可作为判定预后的独立因素(P<0.05)。结论 CAR检测具有高效灵敏便捷经济及创伤小等优点,通过联合检测CRP和Alb对SCLC的临床分期及预后判断具有重要应用价值。
Abstract:
Objective To investigate the correlation between CRP/Alb ratio (CAR) and clinicopathological features of small cell lung cancer (SCLC) and its prognostic value.Methods The CRP and Alb before receiving the treatment of 80 healthy controls and SCLC patients in our center were retrospectively analyzed. CAR values were calculated. The correlation between CAR values and clinicopathological characteristics of SCLC patients was analyzed by chi-square test. The relationship between CAR and prognosis of SCLC was analyzed by Kaplan-Meier method and COX regression model.Result The serum CRP of SCLC patients (6.95 ± 3.21) mg/L was higher than that of healthy control group (3.13 ±1.69) mg/L, with statistical difference (P < 0.05). Alb level (35.71 ± 6.68) g/L was lower than that of healthy control group (45.63 ± 5.78), the difference was statistically significant (P < 0.05). The level of CAR (0.20 ±0.10) was higher than that of healthy control group (0.07 ± 0.04), with statistical difference (P < 0.05). Further analysis showed that CAR was positively correlated with lymph node metastasis and clinical stage (P < 0.05), but not with age, sex, smoking history and tumor size. Survival analysis revealed that patients with high expression of CAR had worse prognosis than those with low expression of CAR (P < 0.05). COX multivariate regression analysis demonstrated that the level of CAR could be used as an independent prognostic factor (P < 0.05). Conclusion CAR detection has the advantages of high efficiency, agility, economy and minimal trauma. The combined detection of CRP and Alb has an important application value in the clinical staging and prognosis of SCLC
更新日期/Last Update: 2019-07-11