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    燕涵, 孙东. 非透析慢性肾脏病患者的超敏C-反应蛋白水平和血红蛋白水平的相关性探究[J]. 徐州医科大学学报, 2019, 39(12): 899-891.
    引用本文: 燕涵, 孙东. 非透析慢性肾脏病患者的超敏C-反应蛋白水平和血红蛋白水平的相关性探究[J]. 徐州医科大学学报, 2019, 39(12): 899-891.
    Study on the relationship between high sensitive C-reactive protein level and hemoglobin level in non-dialysis chronic kidney disease[J]. Journal of Xuzhou Medical University, 2019, 39(12): 899-891.
    Citation: Study on the relationship between high sensitive C-reactive protein level and hemoglobin level in non-dialysis chronic kidney disease[J]. Journal of Xuzhou Medical University, 2019, 39(12): 899-891.

    非透析慢性肾脏病患者的超敏C-反应蛋白水平和血红蛋白水平的相关性探究

    Study on the relationship between high sensitive C-reactive protein level and hemoglobin level in non-dialysis chronic kidney disease

    • 摘要: 目的 探究非透析慢性肾脏病(Chronic kidney disease,CKD)患者的超敏C-反应(High sensitive C-reactive protein,hs-CRP)蛋白水平和血红蛋白(Hemoglobin,Hb)水平的相关性。方法 将80名非透析CKD患者根据hs-CRP水平是否升高分为hs-CRP升高组和hs-CRP正常组,研究其肾功能、Hb、hs-CRP的变化并探讨hs-CRP与Hb的相关性。结果 hs-CRP升高组和hs-CRP正常组在性别、年龄、血肌酐(Serum creatinine,Scr)、尿素氮(Blood urea nitrogen,BUN)、胱抑素C、估算肾小球滤过率(Estimated glomerular filtration rate,eGFR)、CKD分期上差异无统计学意义(P>0.05);hs-CRP升高组的Hb水平明显低于hs-CRP正常组,且hs-CRP升高组的hs-CRP水平明显高于hs-CRP正常组,差异有统计学意义(P<0.05);hs-CRP升高组中hs-CRP水平和Hb水平呈负相关(r= -0.415),差异有统计学意义(P<0.05)。结论 非透析CKD患者体内的贫血程度与微炎症状态密切相关。

       

      Abstract: ob<x>jective To investigate the relationship between the high sensitive C-reactive (hs-CRP) protein level and hemoglobin (Hb) level in non-dialysis chronic kidney disease (CKD) patients. Methods 80 non-dialysis CKD patients were divided into hs-CRP elevation group and hs-CRP normal group according to the hs-CRP level, we researched the changes of renal function indexes, Hb and hs-CRP, investigated the correlation between hs-CRP and Hb. Results There were no statistically significant differences in sex, age, serum creatinine(Scr), b lood urea nitrogen(BUN), cystine C, estimated glomerular filtration(eGFR) and CKD stage between hs-CRP elevation group and hs-CRP group(P>0.05); the level of Hb in hs-CRP elevation group were lower than that in hs-CRP normal group, the level of hs-CRP in hs-CRP elevation group were higher than that in hs-CRP normal group, there were statistically significant differences between them(P < 0.05) ; there was a negative correlation between hs-CRP and Hb in hs-CRP elevation group (r = -0.415), the difference was statistically significant(P < 0.05). Conclusion The degree of anemia is closely related to the state of microinflammation in non-dialysis CKD patients

       

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