Abstract: ob＜x＞jective To investigate the effect of preinfarction angina（PA） on remote ischemic preconditioning（RIPC）in patients with ST-segment elevation myocardial infarction. Methods 153 patients with acute ST-segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention in our hospital were enrolled, randomly divided into the RIPC group and the control group .Then the patients were divided into the PA group and the non-PA group according to the existence of PA. The postoperative troponin peak, CK-MB level and area under the curve of patients in each group and subgroup were observed for statistical analysis. Results The postoperative troponin T peak and the area under the CK-MB curve of the patients in the RIPC group were significantly lower than those in the control group (P < 0.001).In the RIPC group, the area under the CK-MB curve was lower in patients with PA than in patients without PA (P < 0.001).Both the postoperative troponin peak value and the area under the CK-MB curve of patients in the PA group were lower than those in the non-PA group (P < 0.05). Either in group PA or group non-PA,RIPC was effective in reducing the area under the CK-MB curve (P＜0.05); No interaction between RIPC and PA was observed in multiple linear regression analysis (P=0.173). Conclusion Both the remote ischemic preconditioning and preinfarction angina can effectively reduce ischemia reperfusion injury in acute STEMI patients. Furthermore, the protective effect of remote ischemic preconditioning on myocardial injury was not affected by preinfarction angina.