Abstract: ob＜x＞jective Investigate the protective effect of edaravone on the Parkinson’s disease (PD) cell model and its possible mechanism, explore the effect of edaravone on MPP+-induced PC12 cells mitochondria damage protection mechanism, provide a theoretical basis on the treatment of PD. Method A model of Parkinson’s disease was established with 500 μM MPP + induced PC12 cell damage. Eda was used to observe ROS, MDA, mtDNA copy number and ATP production rate. Results MPP + -induced PD model can increase ROS, lipid peroxidation MDA, inhibit mtDNA copy number and mitochondrial respiration in PC12 cells. Conclusion Eda can improve MPP + -induced neurotoxicity. Conclusion Eda has a protective effect on mitochondrial oxidative stress induced by MPP + in PC12 cells. The mechanism may be achieved by inhibiting lipid peroxidation and restoring mitochondrial respiration.