Abstract: 【ob＜x＞jective】 To analyze the ex＜x＞pressions of Periostin and Ki67 in cervical carcinoma , then evaluate the relationship between the positive ex＜x＞pressions of the two indicators and the clinical pathologic features , and prognostic analysis . 【Methods】 Immunohistochemistry was used to detect the ex＜x＞pression of Periostin and Ki67 in 86 cases of cervical carcinoma , 30 cases of normal cervical tissues. The relationships between the positive ex＜x＞pressions of Periostin and Ki67 and the clinical pathologic features in cervical carcinoma were analyzed . Then to assess the correlation between the two indicators and the risk factors affecting the overall survival time after surgery in patients with cervical ca rcinoma. 【Results】In 86 cervical carcinoma tissues , the positive rates of Periostin and Ki67 were significantly higher than those in normal cervical tissues（P all <0.05）. The positive ex＜x＞pressions of Periostin w ere correlated to clinical stage, tumor differentiation, vascular invasion and lymph node me＜x＞tastasis (P all <0.05) . Similarly, the positive ex＜x＞pressions of Ki67 were correlated to clinical stage, tumor differentiation, and lymph node me＜x＞tastasis(P all <0.05) , and there was a positive correlation between the two indexes in 86 cases of cervical carcinoma (γ=0.319，P=0.003) . The overall survival time was significantly lower in patients with Periostin positive cervical carcinoma ( 41.037 months vs 63.672 months ，Log-rank test χ2=15.892，P=0.000) , and the positive ex＜x＞pression of Periostin was an independent prognostic factor for overall survival in patients with cervical carcinoma (HR 3.916,95% CI: 1.022-15.006, P 0.046-0.05) . 【Conclusions】: The high ex＜x＞pressions of Periostin and Ki67 may synergistically participate in the malignant progression of cervical carcinoma. The positive ex＜x＞pression of Periostin may indicate a poor prognosis in cervical carcinoma.