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    毛红森, 江红, 韩正祥. 炎症因子评分对小细胞肺癌预后的辅助评估价值炎症因子评分对小细胞肺癌预后的辅助评估价值[J]. 徐州医科大学学报, 2021, 41(1): 6-11. DOI: 10.3969/j.issn.2096-3882.2021.01.002
    引用本文: 毛红森, 江红, 韩正祥. 炎症因子评分对小细胞肺癌预后的辅助评估价值炎症因子评分对小细胞肺癌预后的辅助评估价值[J]. 徐州医科大学学报, 2021, 41(1): 6-11. DOI: 10.3969/j.issn.2096-3882.2021.01.002
    NLRPLRLRDiagnosis of multiple inflammatory factor scores in the prognosis of SCLC[J]. Journal of Xuzhou Medical University, 2021, 41(1): 6-11. DOI: 10.3969/j.issn.2096-3882.2021.01.002
    Citation: NLRPLRLRDiagnosis of multiple inflammatory factor scores in the prognosis of SCLC[J]. Journal of Xuzhou Medical University, 2021, 41(1): 6-11. DOI: 10.3969/j.issn.2096-3882.2021.01.002

    炎症因子评分对小细胞肺癌预后的辅助评估价值炎症因子评分对小细胞肺癌预后的辅助评估价值

    NLRPLRLRDiagnosis of multiple inflammatory factor scores in the prognosis of SCLC

    • 摘要: 目的 探讨炎症因子评分对小细胞肺癌患者预后的辅助评估作用,及其在临床实践中的应用价值.方法 筛选118例小细胞肺癌患者的临床资料,统计改良格拉斯哥预后评分(mGPS)、中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)和单核细胞-淋巴细胞比值(MLR),运用Kaplan-Meier生存分析和Cox风险比例回归模型来回顾性分析其用于近期疗效和远期预后评估的价值.结果 mGPS、NLR、MLR高分组患者处于广泛期和发生远处转移的比例较高(P<0.05),予以标准治疗后,mGPS、NLR、PLR和MLR低分组客观有效率和疾病控制率明显优于高分组(P<0.05).mGPS、NLR、PLR和MLR高分组与低分组肿瘤无进展生存期(PFS)和总生存期(OS)的差异有统计学意义(P<0.05).多因素预后分析提示,mGPS是小细胞肺癌预后的独立危险因素(HR=0.603,95%CI:0.373-0.973,P=0.038).结论 炎症因子评分mGPS、NLR、PLR和MLR均与小细胞肺癌预后有关,其中mGPS评分可作为评估小细胞肺癌预后的独立危险因素.

       

      Abstract: ob<x>jective This study aimedexplore the auxiliary diagnostic function of inflammatory factor score index in patients with small cell lung cancer and its value in clinical practice. Methods The clinical data of the selected 118 patients with SCLC collected from 244 patients with lung carcinoma were retrospective analyzed. As prognostic factors, the modified Glasgow prognostic score(mGPS), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) were tested as prognostic factors. The relationship between the Inflammatory index and the diagnostic effect on the short-term efficacy and long-term prognosis were retrospective analyzed by Kaplan-Meier survival analysis and Cox risk ratio regression model. Results The elevated groups of mGPS, NLR, and MLR in the selected patients were closely related to tumor staging and pleural me<x>tastasis(P<0.05). After standard treatment, multivariate analyses showed that in the ob<x>jective Response Rate(ORR) and the Disease Control Rate (DCR) statistics, the low group of mGPS, NLR, PLR and MLR was significantly better than the high group (P<0.05). The scores of the mGPS, NLR, PLR MLR groups were negatively correlated with the progression-free survival (PFS) and overall survival (OS) of the selected 118 patients, and the differences between the high and low groups were statistically significant(P<0.0). Multivariate analysis showed that mGPS was an independent risk prognostic factor for SCLC(HR=0.603, 95%CI:0.373∽0.973, P=0.038). Conclution The results shows that the mGPS, NLR, PLR, MLR and SII were associated with prognosis of SCLC. mGPS is an independent risk factor for the prognosis in the SCLC patients

       

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