Abstract:
ob<x>jective This study aimedexplore the auxiliary diagnostic function of inflammatory factor score index in patients with small cell lung cancer and its value in clinical practice. Methods The clinical data of the selected 118 patients with SCLC collected from 244 patients with lung carcinoma were retrospective analyzed. As prognostic factors, the modified Glasgow prognostic score(mGPS), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) were tested as prognostic factors. The relationship between the Inflammatory index and the diagnostic effect on the short-term efficacy and long-term prognosis were retrospective analyzed by Kaplan-Meier survival analysis and Cox risk ratio regression model. Results The elevated groups of mGPS, NLR, and MLR in the selected patients were closely related to tumor staging and pleural me<x>tastasis(P<0.05). After standard treatment, multivariate analyses showed that in the ob<x>jective Response Rate(ORR) and the Disease Control Rate (DCR) statistics, the low group of mGPS, NLR, PLR and MLR was significantly better than the high group (P<0.05). The scores of the mGPS, NLR, PLR MLR groups were negatively correlated with the progression-free survival (PFS) and overall survival (OS) of the selected 118 patients, and the differences between the high and low groups were statistically significant(P<0.0). Multivariate analysis showed that mGPS was an independent risk prognostic factor for SCLC(HR=0.603, 95%CI:0.373∽0.973, P=0.038). Conclution The results shows that the mGPS, NLR, PLR, MLR and SII were associated with prognosis of SCLC. mGPS is an independent risk factor for the prognosis in the SCLC patients