Abstract: In clinic, as a common ischemic eye disease, retinal ischemia-reperfusion injury (RIRI) severely impairs the function of retina, affects the eyesight health of teenagers and has aroused widespread concern in the society. Previous studies have founded several mechanisms which can facilitate RIRI. However, there are still great disputes among scholars on the existing mechanism. Understand and study the different injury mechanisms of RIRI has been of huge importance for the prevention and treatment of retinal ischemic diseases