Abstract: Objective To summarize the etiologic features and utilization patterns of antiepileptic drugs in people with epilepsy in Xuzhou. Methods Epilepsy patients who were treated in Xuzhou Central Hospital from December 2017 to December 2019 were selected. Their clinical data were collected through questionnaire and medical record analysis. Results A total of 199 patients were enrolled in the current study. Cerebrovascular disorders were the most common cause in the adult group (29.9%) and the elderly group (80.0%). Cerebral trauma (75.0%) was the major cause of children secondary epilepsy. More than 46.7% of patients received antiepileptic drug monotherapy. Valproic acid was the most frequently used antiepileptic drug (76.2% for monotherapy and 91.8% for multitherapy). Conclusions The etiologic features vary with the age of patients with epilepsy in Xuzhou. Cerebrovascular disorders are the most common cause of epilepsy among adults and elderly patients. Valproic acid is most widely used for the treatment of epilepsy in Xuzhou.