[1]王忠诚,张玉东,胡献礼,等.徐州地区癫痫发病情况与抗癫痫药物使用情况回顾性队列分析[J].徐州医科大学学报,2022,42(03):175-180.[doi:10.3969/j.issn.2096-3882.2022.03.004]
　Trends in etiologic features and utilization of antiepileptic drugs in Xuzhou: a retrospective cohort study[J].Journal of Xuzhou Medical University,2022,42(03):175-180.[doi:10.3969/j.issn.2096-3882.2022.03.004]
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徐州地区癫痫发病情况与抗癫痫药物使用情况回顾性队列分析()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
42
期数:
2022年03期
页码:
175-180
栏目:
出版日期:
2022-03-25

文章信息/Info

Title:
Trends in etiologic features and utilization of antiepileptic drugs in Xuzhou: a retrospective cohort study
作者:
王忠诚1; 张玉东2; 胡献礼3; 刘超侠1*
1. 徐州医科大学基础医学院病理生理学教研室，江苏 徐州221004；2. 徐州医科大学外科总实验室；3. 徐州市中心医院急诊科，江苏 徐州221009
关键词:
癫痫; 病因; 抗癫痫药物; 丙戊酸
分类号:
R742.1
DOI:
10.3969/j.issn.2096-3882.2022.03.004
文献标志码:
A
摘要:
目的评估徐州市癫痫发病特点及抗癫痫药物的使用特点。方法选取2017年12月—2019年12月于徐州市中心医院就诊的癫痫患者。通过问卷调查和病历复核采集临床资料。结果本研究共募集199例患者，脑血管疾病是成人组（29.9%）和老年组（80.0%）患者最常见的癫痫病因，脑外伤（75.0%）是儿童继发性癫痫的主要原因。超过46.7%的患者使用一种抗癫痫药物进行治疗；无论使用单一抗癫痫药物治疗还是多种抗癫痫药物联合使用，丙戊酸都是最常使用的抗癫痫药物（单药治疗76.2%，联合使用91.8%）。结论徐州地区癫痫患者的病因随年龄的不同而有所差异，脑血管疾病是成年和老年患者最常见的病因。丙戊酸是徐州地区最常使用的抗癫痫药物。
Abstract:
ob＜x＞jective: To assess the evolution of etiologic features and antiepileptic drug (AED) treatment patterns in Intensive Care Unit from 2017 to 201 9.Methods: A retrospective cohort study was performed by collecting the medical records of patients newly diagnosed with epilepsy in Xuzhou Central Hospital from December 201 7 to December 201 9. Patients were followed until the end of data availability. Results: Among 1 99 patients, cerebrovascular disorder was the most common cause in groups of adults (28.6%) and elderly individuals (78.1%). Cerebral trauma (20%) was the major cause of symptomatic epilepsy among children. More than 46.6% of participants were using AED monotherapy. Valproic acid (VPA) was the AED most frequently utilized as monotherapy (76.9%) and within multitherapy (91.7%). Conclusions: Our data showed that the etiologic features varied with the age of patients with epilepsy. Cerebrovascular disorders are the most common cause of epilepsy among adults and elderly individuals . VPA is widely used for the treatment of epilepsy in Xuzhou

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81801168）*通信作者,E-mail：lcxhxlhyt@163.com
更新日期/Last Update: 2022-05-09