[1]朱丽丽,赵汉青,郭莉莉,等.18F-FDG PET/CT参数预测弥漫大B细胞淋巴瘤中期疗效的应用研究[J].徐州医科大学学报,2022,42(05):369-374.[doi:10.3969/j.issn.2096-3882.2022.05.011]
 Predictive Value of 18F-FDG PET/CT parameters for Interim Treatment Response in Patients with Diffuse Large B-cell Lymphoma[J].Journal of Xuzhou Medical University,2022,42(05):369-374.[doi:10.3969/j.issn.2096-3882.2022.05.011]
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18F-FDG PET/CT参数预测弥漫大B细胞淋巴瘤中期疗效的应用研究()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
42
期数:
2022年05期
页码:
369-374
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
Predictive Value of 18F-FDG PET/CT parameters for Interim Treatment Response in Patients with Diffuse Large B-cell Lymphoma
作者:
朱丽丽1赵汉青1郭莉莉1孟闫凯2史跃1王安明1陈凯1张晓俊1刘忱1王增慧1孙晨曦1徐凯2*
1. 徐州医科大学附属淮海医院医学影像科,江苏徐州221004;2. 徐州医科大学附属医院医学影像科,江苏徐州221002
关键词:
弥漫大B细胞淋巴瘤18氟-脱氧葡萄糖PET/CT疗效评估
分类号:
R730.44
DOI:
10.3969/j.issn.2096-3882.2022.05.011
文献标志码:
A
摘要:
目的探讨18氟-脱氧葡萄糖(18F-FDG) PET/CT参数对弥漫大B细胞淋巴瘤(DLBCL)R-CHOP化疗中期疗效的预测价值。方法选取2014年7月—2019年6月徐州医科大学附属医院收治并接受R-CHOP化疗的DLBCL患者,共79例。根据中期疗效将上述患者分为完全缓解(CR)组和非完全缓解(非CR)组。比较2组间治疗前PET/CT定量参数的差异,采用受试者工作特征(ROC)曲线对变量取最佳阈值。采用多因素logistic回归分析评估中期疗效的独立预测因素,并用ROC曲线分析评价logistic 回归模型的效能。结果79例DLBCL患者化疗中期CR 48例,非CR组31例(PR17例、SD5例、PD9例)。2组间最大病灶肿瘤代谢体积(MTVmax)、总肿瘤代谢体积(MTVsum)、最大病灶糖酵解(TLGmax)、总糖酵解(TLGsum)、最大病灶的最大直径(Dmax)、乳酸脱氢酶(LDH)水平、国际预后指数(IPI)、受侵结外脏器数目和病灶内坏死情况比较,差异有统计学意义(P<0.05)。MTVmax、MTVsum、TLGmax、TLGsum、Dmax预测中期疗效的最佳阈值分别为57.2 cm3、45.3 cm3、756.0 g、1 977.1 g和6.6cm,其中Dmax效能最高。多因素分析显示Dmax和IPI是中期疗效的独立预测因素。结论18F-FDG PET/CT参数对DLBCL患者R-CHOP化疗中期疗效具有预测价值,可为临床治疗策略的选择和及时调整提供重要依据。
Abstract:
ob<x>jective To investigate the predictive value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters for interim treatment response in patients with diffuse large B-cell lymphoma (DLBCL) receiving R-CHOP chemotherapy. Methods 79 DLBCL patients who received R-CHOP chemotherapy were divided into complete response (CR) group and incomplete response (non-CR) group according to the interim treatment response. The differences of pre-treatment PET/CT quantitative parameters were compared between the two groups,and the PET/CT parameters with predictive value for the interim treatment response were searched. Results Among the 79 patients, 48 patients were included in CR group and 31 patients (PR 17 cases,SD 5 cases,PD 9 cases) were included in non-CR group. MTVmax,MTVsum,TLG max,TLGsum,Dmax,IPI,LDH,number of extranodal organ involvement and necrosis were significantly different between the two groups. The optimal cutoff values for MTVmax,MTVsum,TLGmax,TLGsum and Dmax to predict interim treatment response were 57.2cm3,45.3cm3,756.0g,1977.1g,6.6cm,respectively. Dmax had the highest efficacy. Multivariate analysis showed that Dmax and IPI were independent predictive indicators for interim treatment response. Conclusions 18F-FDG PET/CT parameters may be used as predictive factors for interim treatment response in DLBCL patients treated with R-CHOP,they can provide important information for the selection and timely adjustment of clincal treatment strategy.

备注/Memo

备注/Memo:
基金项目:徐州市科技局重点研发计划(社会发展)(KC20159);江苏省中医药科技发展计划项目(MS2021100)*通信作者,E-mail:xukaixz@163.com
更新日期/Last Update: 2022-06-07