Abstract:
ob<x>jective: To investigate the predictive values of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), carbohydrate antigen 199 (CA199), carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125) and alpha fetoprotein (AFP) in patients with type 2 diabetic retinopathy.Methods: 306 patients with type 2 diabetes (T2D) were enrolled and divided into diabetic retinopathy (DR, n=134) and non-DR group (NDR, n=172). The levels of serum tumor markers and clinical characteristics were compared between the two groups. Spearman correlation analysis was employed to analyze the correlation between serum tumor markers and clinical characteristics. The logistic multiple regression was implemented to analyze the risk factors of DR. The area under curve (AUC) was obtained.Results: Age, history of T2D, CEA, NSE, CA199, CA153, CA125, ALB / SCR, Cys-C, blood urea nitrogen (BUN) and HbA1c in DR group were significantly higher than those of NDR group (P < 0.05). CEA and CA199 were positively correlated with HbA1c, NSE was positively correlated with TC and LDL-C, and CA125 was positively correlated with ALB / SCR and HDL-C (P < 0.05). The levels of tumor markers were significantly increased with T2D history and age (P < 0.05). The history of T2D, ALB / SCR, NSE, CA199 and CA125 were risk factors for DR (P < 0.05, or > 1). The AUC of CEA, NES, CA199, CA153 and CA125 in DR patients were 0.669, 0.798, 0.674, 0.687 and 0.669, respectively (P < 0.05). Diagnostic sensitivity and specificity of NSE was 82.8% and 67.4%.Conclusion: CEA, NES, CA199, CA153 and CA125 have certain diagnostic value for DR.