Abstract:
ob<x>jective: To investigate the risk factors and prognostic significance of secondary thrombocytopenia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: The clinical data of 264 patients who received allo-HSCT in the affiliated Hospital of Xuzhou Medical University from January 2013 to June 2020 were retrospectively analyzed. According to the platelet level of +60d after transplantation, the patients were divided into thrombocytopenia group and control group. The risk factors and prognostic significance of thrombocytopenia were analyzed. Results: The infection rate of CMV in the thrombocytopenia group was significantly higher than that in the control group (P =0.002). Multivariate analysis showed that CMV infection was an independent risk factor for secondary thrombocytopenia. The 1-year and 3-year overall survival (OS) rate and disease-free survival (DFS) rate in the thrombocytopenia group was lower than that in the control group (P<0.001). The 1-year and 3-year non-relapse mortality in the thrombocytopenia group was higher than that in the control group. Multivariate analysis showed that +60d PLT<30×109/L was an independent risk factor affecting OS rate, DFS rate and NRM(P<0.001). Conclusion: CMV infection is associated with secondary thrombocytopenia after allo-HSCT, and the prognosis of patients with secondary thrombocytopenia is poor