Abstract: ob＜x＞jective The purpose of this study was to compare the application value of International Index of Erectile Function-5 ( IIEF-5)/Erection Hardness Score (EHS) score and phosphodiesterase-5 inhibitor (PDE -5i) combined with RigiScan-ba＜x＞sed audiovisual sexual stimulation (AVSS) test in evaluating erectile dysfunction (ED) . Methods Between November 2020 and November 2021, the clinical data of 31 patients with ED at our institution were retrospectively evaluated. All patients underwent the IIEF-5/EHS and PDE-5i combined with RigiScan-ba＜x＞sed AVSS test. According to the RigiScan test results, the patients were divided into ED group and normal group. The RigiScan related parameters and the scores of IIEF-5 /EHS were analyzed. Results The median age of the patient was 32 years, and the median duration of disease was 12 months. According to ED criteria, there were 24 cases with ED (64.5%, ED group) and 7 cases without ED (22.6%, normal group). The effective erection time (rigidity ≥60%) and average tip/ba＜x＞se rigidity in ED group were significantly lower than those in normal group ( all P < 0.05), but there was no significant difference in age, duration of disease and body mass index ( BMI) ( all P > 0.05). The median IIEF-5 score of was 9 (4-16), and the grade I, II, III and IV hardness of EHS were 4, 8, 12 and 7 cases respectively. Spearman test showed that EHS was positively correlated with effective erection time and average tip/ba＜x＞se rigidity ( all P＜0.05); IIEF-5 score was not statistically significant (all P＞0.05). The EHS≤grade III (sensitivity: 91.67%; specificity: 71.43%) showed the highest diagnostic value. Conclusions EHS is a rapid and practical method for screening ED and is positively correlated with PDE-5i combined with RigiScan-ba＜x＞sed AVSS test results. The EHS≤grade III showed the highest diagnostic value