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    周晗, 许祥影, 吴风, 张佳依, 沈雅静, 张威, 季晶晶, 周亚, 王丹. 天舒胶囊对甲醛致小鼠记忆损害的影响[J]. 徐州医科大学学报, 2017, 37(6): 369-371.
    引用本文: 周晗, 许祥影, 吴风, 张佳依, 沈雅静, 张威, 季晶晶, 周亚, 王丹. 天舒胶囊对甲醛致小鼠记忆损害的影响[J]. 徐州医科大学学报, 2017, 37(6): 369-371.
    shu
    ZHOU Han, XU Xiangying, WU Feng, ZHANG Jiayi, SHEN Yajing, ZHANG Wei, JI Jingjing, ZHOU Ya, WANG Dan. Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice[J]. Journal of Xuzhou Medical University, 2017, 37(6): 369-371.
    Citation: ZHOU Han, XU Xiangying, WU Feng, ZHANG Jiayi, SHEN Yajing, ZHANG Wei, JI Jingjing, ZHOU Ya, WANG Dan. Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice[J]. Journal of Xuzhou Medical University, 2017, 37(6): 369-371.
    shu

    天舒胶囊对甲醛致小鼠记忆损害的影响

    Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice

      摘要
    • 摘要: 目的 观察天舒胶囊对甲醛所致小鼠记忆损害的影响。方法 将小鼠随机分为5组：生理盐水组（NS组），甲醛组（FA组），天舒胶囊低剂量（0.3 g·kg-1） 组（CLL组），天舒胶囊中剂量（0.6 g·kg-1） 组（CLM 组），天舒胶囊高剂量（1.2 g·kg-1）组（CLH组）。用避暗实验分别观察小鼠的潜伏期和错误次数。结果 与NS组相比，FA组的潜伏期缩短（P<0.05），错误次数明显增多（P<0.01）；与FA组相比，CLH组的潜伏期明显延长（P<0.01)，CLL组、CLM组、CLH组错误次数均明显减少（P<0.01)。结论 天舒胶囊对甲醛所致的小鼠记忆损害具有保护作用。

       

      Abstract: Objective To observe the effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice. Methods Mice were randomly divided into five groups: a normal saline group (Group NS), a formaldehyde group (Group FA), a low dose of Tianshu capsule (0.3 g·kg-1) group (Group CLL), a middle dose of Tianshu capsule (0.6 g·kg-1) group (Group CLM), and a high dose of Tianshu capsule (1.2 g·kg-1) group (Group CLH). The latency and number of errors in mice were observed by the step-through test. Results Compared with Group NS, Group FA presented obviously shorter latency (P<0.05) and an increased number of errors (P<0.01). Compared with Group FA, the latency was remarkably extended in Group CLH (P<0.01), while the number of errors was marked decreased for Groups CLL, CLM and CLH (P<0.01). Conclusions Tianshu capsules can improve the memory impairment induced by formaldehyde in mice.

       

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