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    李鑫明, 苏建林. 氟比洛芬酯对下肢骨折患者血浆可溶性ICAM -1表达和术后疼痛的影响[J]. 徐州医科大学学报, 2017, 37(10): 661-663.
    引用本文: 李鑫明, 苏建林. 氟比洛芬酯对下肢骨折患者血浆可溶性ICAM -1表达和术后疼痛的影响[J]. 徐州医科大学学报, 2017, 37(10): 661-663.
    LI Xinming, SU Jianlin. Effects of flurbiprofen axetil on the level of plasma soluble ICAM-1 and postoperative pain in patients with lower limb fracture[J]. Journal of Xuzhou Medical University, 2017, 37(10): 661-663.
    Citation: LI Xinming, SU Jianlin. Effects of flurbiprofen axetil on the level of plasma soluble ICAM-1 and postoperative pain in patients with lower limb fracture[J]. Journal of Xuzhou Medical University, 2017, 37(10): 661-663.

    氟比洛芬酯对下肢骨折患者血浆可溶性ICAM -1表达和术后疼痛的影响

    Effects of flurbiprofen axetil on the level of plasma soluble ICAM-1 and postoperative pain in patients with lower limb fracture

    • 摘要: 目的探讨氟比洛芬酯对下肢骨折患者血浆可溶性细胞间黏附分子-1(sICAM -1)表达和术后疼痛的影响。方法60例下肢骨折择期拟行手术治疗的患者随机分为对照组(C组)和氟比洛芬酯组(F组),每组30例。2组均采用硬膜外麻醉,给药方法一致。氟比洛芬酯组硬膜外给药前静脉注射氟比洛芬酯1 mg/kg。监测2组患者麻醉前、麻醉后2 h的脉搏氧饱和度(SpO2)、心率(HR)、收缩压(SBP)、舒张压(DBP)的变化,酶联免疫吸附法(ELISA)测定麻醉前、麻醉后2 h、术后4 h血浆sICAM-1的表达,视觉模拟评分法(VAS)评估患者术后1、6、12、24 h的疼痛感觉程度。结果2组患者一般资料比较差异无统计学意义(P>0.05);2组患者各时点SBP、DBP、HR、SpO2比较差异无统计学意义(P>0.05);与麻醉前比较,2组患者麻醉后2 h、术后4 h血浆sICAM-1的表达均增加;与C组比较,F组患者麻醉后2 h、术后4 h血浆sICAM-1的表达以及术后1、6、12、24 h的VAS评分均降低(P<0.05)。结论氟比洛芬酯抑制下肢骨折患者血浆sICAM-1的表达,具有一定的抗炎作用,并可以减轻患者的术后疼痛。 关键词:氟比洛芬酯;下肢骨折;血浆可溶性细胞间黏附分子-1;疼痛

       

      Abstract: ObjectiveTo investigate the effects of flurbiprofen axetil on the level of plasma soluble intercellular adhesion molecule-1 (sICAM-1) and postoperative pain in patients with lower limb fracture. MethodsA total of 60 patients who were scheduled to receive surgical treatment due to acute lower limb fracture were randomly divided into two groups (n=30): a control group (Group C) and a flurbiprofen axetil group (Group F). All patients were subject to epidural anesthesia through the same route of adminiatration. Patients in Group F were intravenously injected with 1 mg/kg flurbiprofen axetil before epidural administration. The changes in their systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SpO2) were recorded before anesthesia and 2 h after anesthesia. The level of plasma sICAM-1 was evaluated by ELISA before anesthesia, 2 h after anesthesia and 4 h after operation. The visual analog scale (VAS) was assessed at 1, 6, 12 and 24 h after operation. ResultsNo statistical difference was found as to age, gender, weight, the time of operation and the degree of trauma among the two groups (P>0.05). No statistical difference was found as to SBP, DBP, HR, SpO2 at each points (P>0.05). The level of plasma sICAM-1 was higher 2 h after anesthesia and 4 h after operation, compared with that before anesthesia. Compared with the Group C, the amount of plasma sICAM-1 was decreased 2 h after anesthesia and 4 h after operation. Meanwhile, the VAS was reduced at 1 h, 6 h, 12 h and 24 h after operation in Group F, compared with Group C P<0.05). ConclusionsFlurbiprofen axetil may inhibit the expression of plasma sICAM-1, and produce anti-inflammatory effects and can relieve postoperative pain in patients with lower limb fracture.

       

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