[1]李昕昱,胡朋,李青云,等.癫痫患者脑脊液中多巴胺的改变及意义[J].徐州医科大学学报,2017,37(08):534-536.
　LI Xinyu,HU Peng,LI Qingyun,et al.Changes and significance of dopamine in the cerebrospinal fluid of patients with epilepsy[J].Journal of Xuzhou Medical University,2017,37(08):534-536.
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癫痫患者脑脊液中多巴胺的改变及意义()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
37
期数:
2017年08期
页码:
534-536
栏目:
出版日期:
2017-08-25

文章信息/Info

Title:
Changes and significance of dopamine in the cerebrospinal fluid of patients with epilepsy
作者:
李昕昱; 胡朋; 李青云; 袁蕊; 樊红彬*
徐州医科大学附属医院神经内科，江苏徐州221002
Author(s):
LI Xinyu;  HU Peng;  LI Qingyun;  YUAN Rui;  FAN Hongbin
Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China
关键词:
癫痫; 脑脊液; 多巴胺; 认知功能
Keywords:
epilepsy;  cerebrospinal fluid;  dopamine;  cognitive function
分类号:
R742.1
文献标志码:
A
摘要:
目的探讨癫痫（EP）患者脑脊液中多巴胺（DA）水平的改变及意义。方法选择EP患者35例为EP组，根据是否为药物难治性癫痫分为难治性癫痫组9例，非难治性癫痫组26例。设立对照组25例。采用蒙特利尔认知评估量表（MoCA）对EP患者进行认知功能评分，采用高效液相色谱法检测脑脊液DA水平，采用Spearman相关分析脑脊液DA水平与认知功能评分的关系。结果EP组患者脑脊液DA水平高于对照组，差异有统计学意义（P<0.01），难治性癫痫组脑脊液DA水平与非难治性癫痫组的差异无统计学意义（P>0.05）。EP患者脑脊液DA水平与MoCA量表评分无显著相关性（P>0.05）。结论脑脊液DA水平升高可能与EP的发生发展有关，但DA水平与难治性癫痫以及是否合并认知功能障碍无关。
Abstract:
ObjectiveTo investigate the changes and significance of dopamine (DA) in the cerebrospinal fluid of patients with epilepsy. MethodsA total of 35 epilepsy patients was set as an EP group and then were sub-divided into an intractable epilepsy group (9 patients) and a non-refractory epilepsy group (26 patients). Their cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA) Scale. Their levels of DA in the cerebrospinal fluid were measured by high performance liquid chromatography (HPLC). The association of DA in the cerebrospinal fluid with MoCA scores was analyzed by Spearman correlation analysis. ResultsThe level of DA in the cerebrospinal fluid in the EAP group were significantly higher than that in the control group (P<0.01). No significant difference was found in DA level between the intractable and non-refractory epilepsy groups (P>0.05). There was no significant correlation between DA level and MoCA scores in epilepsy patients (P>0.05). ConclusionsThe elevated level of DA in the cerebrospinal fluid may be related to the development of EP, but the level of DA is not associated with refractory epilepsy and cognitive dysfunction.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：江苏省重点实验室开放研究课题（KF-XY201503） *通信作者，E-mail：fandoc@126.com
更新日期/Last Update: 2017-11-09