Abstract: Objective To investigate the significance of the blood lipid, total bilirubin and uric acid levels in male patients with coronary heart disease and type?2?diabetes, which provided a reference for the diagnosis. Methods A total of 60 male patients who were diagnosed with coronary heart disease and underwent coronary angiography in the department of cardiology of our Hospital were Continuous selected in the current study as control group. Meanwhile, another 75 male patients who were diagnosed with coronary heart disease by coronary angiography and type 2 diabetes were Continuous selected as treatment group. Their clinical data were collected. Comparing the changes of the blood lipid, total bilirubin and uric acid levels between the two groups. Results There was no significant difference in age, that of men was smoking, BMI, hypertension and the history of hypertension between the two groups (P > 0.05). Level of the cholesterol, triglyceride, LDL-C and uric acid of treatment group was significantly higher than that of control group (P < 0.05). However, the HDL-C and bilirubin levels were significantly lower than that in control group compared with treatment group (P < 0.05). The serum bilirubin level was negatively correlated with the level of TC、LDL-C and UA (P < 0.05). Conclusions In the treatment of male coronary heart disease patients with type?2?diabetes, except for the control of blood glucose, we should also reduce lipid and control the bilirubin and uric acid levels