Abstract:
Objective To investigate the relationship between the serum levels of Hcy (homocysteine), hs-CRP (serum high-sensitivity C-reactive protein) and IL-8 (interleukin-8) and the efficacy of patients with type 2 diabetes mellitus (T2DM) complicated with depression. Methods 110 patients with T2DM and depression diagnosed in our hospital from December 2015 to December 2017 were enrolled as subjects. All patients were treated with conventional hypoglycemic therapy combined with antidepressant therapy. Patients were divided into excellent group (n=55) and general group (n=55) by treatment with se1f-rating depression sca1e (SDS). The general clinical data of the two groups of patients, the degree of psychological disorder and blood glucose changes before and after treatment were compared. Serum Hcy levels were measured by circulating enzymatic method, hs-CRP levels were determined by immunoturbidimetry, and serum IL8 levels were detected by E1ISA method. The Pearson product moment correlation coefficient was used to analyze the correlation between the patient’s efficacy and the three serum markers. Results After treatment, the SDS and HAMD scores of the two groups were statistically significant (P<0.05), and there was no significant difference in SAS and HAMA scores (both P>0.05). After treatment, the SDS and HAMD scores of the excellent group were significantly lower than those of the general group (both P<0.05). The blood glucose levels of the two groups were decreased after treatment (P<0.05), but the difference between the two groups was not statistically significant (P>0.05). After treatment, the levels of each marker in the two groups were significantly lower than those before treatment, and the level of the excellent group was significantly lower than that in the general group (all P < 0.05). There were positive correlations between the three serum markers and SDS scores in the treatment group (all P < 0.05); Hcy was the strongest correlation with the change of depression (P < 0.05). Conclusions The level of serum Hcy, hs-CRP and IL8 levels after treatment was positively correlated with the degree of depression in patients with T2DM and depression, which may provide a clinical basis for improving the efficacy of patients with T2DM and depression.