Abstract:
Objective To observe the effects of different doses of subcutaneous injection of lidocaine on incision healing in mice. Methods Kunming mice were randomly divided into 4 groups (n = 10 each) : normal saline (NS) group and lidocaine 10 mg·kg-1, 20 mg·kg-1, 40 mg·kg-1 (L10, L20, L40) group. Corresponding dose of lidocaine was subcutaneously injected in L10, L20 and L40 group 10 min before skin incising, while the same volume of NS was administered in NS group. The length of incision was measured 72 h and 96 h after the operation in each group. The number of the healing mice was daily recorded from the fifth to the tenth day, and the average incision healing time and daily cumulative incision healing rate were calculated in each group. Results Compared with NS group, the incision length shortened evidently in L40 group (P < 0.01) 72 h after the operation; the incision length shortened in L20 and L40 group (P < 0.05, P < 0.01) 96 h after the operation. The average incision healing time in L10, L20 and L40 group was less than NS group, among them L40 group was the shortest. Meanwhile, daily cumulative incision healing rate in L10, L20 and L40 group was higher than NS group. Conclusion 20 mg·kg-1 and 40 mg·kg-1 lidocaine can promote incision healing in mice.