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    王丹. 利多卡因对小鼠切口愈合的影响[J]. 徐州医科大学学报, 2019, 39(12): 878-880.
    引用本文: 王丹. 利多卡因对小鼠切口愈合的影响[J]. 徐州医科大学学报, 2019, 39(12): 878-880.
    Effects of lidocaine on incision healing in mice LI Zhe1, WANG Jiahao1, PAN Haojie1, TAN Cheng1, YU Huiqian1,[J]. Journal of Xuzhou Medical University, 2019, 39(12): 878-880.
    Citation: Effects of lidocaine on incision healing in mice LI Zhe1, WANG Jiahao1, PAN Haojie1, TAN Cheng1, YU Huiqian1,[J]. Journal of Xuzhou Medical University, 2019, 39(12): 878-880.

    利多卡因对小鼠切口愈合的影响

    Effects of lidocaine on incision healing in mice LI Zhe1, WANG Jiahao1, PAN Haojie1, TAN Cheng1, YU Huiqian1,

    • 摘要: 目的 观察皮下注射不同剂量利多卡因(Lidocaine,L)对小鼠切口愈合的影响。方法 将昆明种小鼠随机分为4组( n = 10):生理盐水(NS)组、利多卡因10 mg·kg -1、20 mg·kg -1和40 mg·kg -1(L10、L20、L40)组。L10组、L20组、L40组分别于切皮前10 min皮下注射相应剂量的利多卡因,NS组于切皮前10min皮下注射等容积的生理盐水。切皮后第72 h及96 h测量各组小鼠切口长度,并于第5 - 10天记录各组小鼠每天的愈合只数,计算各组小鼠平均愈合天数和每天切口累计愈合率。结果 与NS组相比,术后72 h,L40组切口长度明显缩短(P < 0.01 );术后96 h,L20组及L40组切口长度缩短(P < 0.05,P < 0.01);L10组、L20组和L40组小鼠切口平均愈合天数均短于NS组,其中以L40组最短。L10组、L20组及L40组小鼠每天切口累计愈合率高于NS组。结论 20 mg·kg -1、40 mg·kg -1利多卡因可促进小鼠切口的愈合。

       

      Abstract: Objective To observe the effects of different doses of subcutaneous injection of lidocaine on incision healing in mice. Methods Kunming mice were randomly divided into 4 groups (n = 10 each) : normal saline (NS) group and lidocaine 10 mg·kg-1, 20 mg·kg-1, 40 mg·kg-1 (L10, L20, L40) group. Corresponding dose of lidocaine was subcutaneously injected in L10, L20 and L40 group 10 min before skin incising, while the same volume of NS was administered in NS group. The length of incision was measured 72 h and 96 h after the operation in each group. The number of the healing mice was daily recorded from the fifth to the tenth day, and the average incision healing time and daily cumulative incision healing rate were calculated in each group. Results Compared with NS group, the incision length shortened evidently in L40 group (P < 0.01) 72 h after the operation; the incision length shortened in L20 and L40 group (P < 0.05, P < 0.01) 96 h after the operation. The average incision healing time in L10, L20 and L40 group was less than NS group, among them L40 group was the shortest. Meanwhile, daily cumulative incision healing rate in L10, L20 and L40 group was higher than NS group. Conclusion 20 mg·kg-1 and 40 mg·kg-1 lidocaine can promote incision healing in mice.

       

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