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    董爱华, 王赤, 柯丽琴. β-抑制蛋白2、钙中性蛋白酶2表达与乙型肝炎患者肝纤维化的相关性分析[J]. 徐州医科大学学报, 2021, 41(2): 127-131. DOI: 10.3969/j.issn.2096-3882.2021.02.010
    引用本文: 董爱华, 王赤, 柯丽琴. β-抑制蛋白2、钙中性蛋白酶2表达与乙型肝炎患者肝纤维化的相关性分析[J]. 徐州医科大学学报, 2021, 41(2): 127-131. DOI: 10.3969/j.issn.2096-3882.2021.02.010
    shu
    Correlation between the expression of β-arrestin2, calpain 2 and Hepatic Fibrosis in patients with Hepatitis B[J]. Journal of Xuzhou Medical University, 2021, 41(2): 127-131. DOI: 10.3969/j.issn.2096-3882.2021.02.010
    Citation: Correlation between the expression of β-arrestin2, calpain 2 and Hepatic Fibrosis in patients with Hepatitis B[J]. Journal of Xuzhou Medical University, 2021, 41(2): 127-131. DOI: 10.3969/j.issn.2096-3882.2021.02.010
    shu

    β-抑制蛋白2、钙中性蛋白酶2表达与乙型肝炎患者肝纤维化的相关性分析

    Correlation between the expression of β-arrestin2, calpain 2 and Hepatic Fibrosis in patients with Hepatitis B

      摘要
    • 摘要: 目的 探讨β-抑制蛋白2(β-arrestin 2)、钙中性蛋白酶2(calpain 2)表达与乙型肝炎(CHB)患者肝纤维化的相关性.方法 选取2016年1月—2018年4月当阳市人民医院肝病感染科收治的接受肝穿刺组织病理活检的102例CHB患者作为CHB组,根据肝纤维化程度,分为轻度肝纤维化46例,重度肝纤维化30例,肝硬化26例.选取同期30例肝破裂患者作为对照组.比较各组间肝组织β-arrestin 2和calpain 2 mRNA和蛋白表达水平,血清透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)水平,并进行相关性分析.结果 CHB组肝组织β-arrestin 2和calpain 2 mRNA和蛋白表达水平高于对照组,差异有统计学意义(P<0.05).CHB组血清HA、PCⅢ、Ⅳ-C、LN水平均明显高于对照组,差异有统计学意义(P<0.05).肝硬化患者肝组织β-arrestin 2、calpain 2 mRNA表达及血清HA、PCⅢ、Ⅳ-C、LN水平高于轻度肝纤维化和重度肝纤维化患者,差异有统计学意义(P<0.05);重度肝纤维化患者肝组织β-arrestin 2、calpain 2 mRNA表达及血清HA、PCⅢ、Ⅳ-C、LN水平高于轻度肝纤维化患者,差异有统计学意义(P<0.05).经过Pearson相关性分析,β-arrestin 2、calpain 2 mRNA表达与CHB患者肝纤维化指标均呈正相关(P<0.05).结论 β-arrestin 2、calpain 2与CHB患者肝纤维化程度密切相关,可为肝纤维化的病变过程提供参考依据,并且可能是潜在的辅助检测指标.

       

      Abstract: Objective To investigate the correlation between the expression of β-arrestin2, calpain 2 and Hepatic Fibrosis in patients with Hepatitis B. Methods From January 2016 to April 2018, 102 CHB patients with liver biopsy were selected as CHB group. According to the degree of liver fiber, they were divided into mild hepatic fibrosis (46 cases) and severe hepatic fibrosis (30 cases). 26 cases of liver cirrhosis. 30 patients with liver transplantation were selected as control group. The expression levels of β-arrestin2 and calpain 2 mRNA and protein in liver tissues and the levels of serum HA, PC III, IV-C, LN were compared among the groups and the correlation analysis was carried out. Results The expression levels of β-arrestin2 and calpain 2 mRNA and protein in liver tissue in the CHB group were significantly higher than those in the control group (P<0.05). The serum levels of HA, PC III, IV-C, LN in CHB group were significantly higher than those in control group (P<0.05). The expression of β-arrestinin-2, calpain2 mRNA and the level of serum HA, PC III, IV-C, LN in patients with liver cirrhosis were significantly higher than those in mild and severe hepatic fibrosis (P<0.05). The expression of β-arrestinin-2, calpain2 mRNA and the level of serum HA, PC III, IV-C, LN in patients with severe hepatic fibrosis were significantly higher than those in mild hepatic fibrosis (P<0.05). By pearson correlation analysis, the expression of β-arrestinin-2, calpain2 mRNA was positively correlated with hepatic fibrosis index (P<0.05). Conclusion β-arrestinin-2, calpain2 mRNA is closely related to the degree of hepatic fiber in CHB patients, which may be a potential auxiliary index for the process of hepatic fibrosis.

       

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