[1]李莉,南宇飞,赵天娇,等.脐血IL-6在早产儿早发型败血症的诊断价值[J].徐州医科大学学报,2020,40(11):834-838.[doi:10.3969/j.issn.2096-3882.2020.11.012]
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脐血IL-6在早产儿早发型败血症的诊断价值()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年11期
页码:
834-838
栏目:
出版日期:
2020-11-25

文章信息/Info

作者:
李莉 南宇飞 赵天娇 赵辉 张倩 李飞天 王亚娟
北京市顺义区妇幼保健院新生儿科,北京 101300;航天中心医院老年医学二科,北京 100049;国家儿童医学中心,首都医科大学附属北京儿童医院新生儿中心,北京 100045
关键词:
早产儿 败血症 细胞因子
DOI:
10.3969/j.issn.2096-3882.2020.11.012
文献标志码:
A
摘要:
目的 检测早产儿脐血中白细胞介素(IL-6)的水平,评价其在早产儿早发型败血症的诊断价值.方法 选取2017年1月—2018年1月北京市顺义区妇幼保健院收治的早发型败血症早产儿作为败血症组,共39例,同期入院的非败血症早产儿作为非败血症组,共53例.收集入组病例的相关临床资料.采用ELISA法测定脐血和外周血IL-6水平,采用ROC曲线计算脐血及外周血IL-6诊断早发型早产儿败血症的临界值、灵敏度和特异度,并计算ROC曲线下面积(AUC).结果 与非败血症组相比,败血症组的出生体重更低,胎膜早破时间更早;少吃、少哭、少动、腹胀、皮肤发花的发生率更高,差异有统计学意义(P<0.05).实验室指标,乳酸、总胆红素、C反应蛋白、脐血及外周血IL-6均更高,差异有统计学意义(P<0.05).根据ROC曲线可知,脐血IL-6的AUC为0.757,95%CI(0.651~0.863),临界值为17.6 ng/L,灵敏度为56.4%,特异度为94.3%;外周血IL-6的AUC为0.768,95%CI(0.665~0.871),临界值为2.05 ng/L,灵敏度为69.2%,特异度为83.0%.结论 脐血IL-6在败血症早期明显升高,在诊断早产儿早发型败血症中可能具有临床意义.
Abstract:
Objective: To evaluate the diagnostic value of IL-6 and TNF- alpha levels in cord blood and peripheral blood of premature infants.Methods: Thirty-nine premature infants diagnosed as early onset sepsis were selected as the observation group and 53 non-septic premature infants admitted to hospital at the same time as the control group. Relevant clinical data were collected. The levels of IL-6 in cord blood and peripheral blood were measured by ELISA. ROC curves of cord blood and peripheral blood IL-6 in the diagnosis of sepsis were made to explore the significance of cord blood and peripheral blood IL-6 in the diagnosis of premature infants with early onset sepsis. Result:The birth weight of septicemia group was lower than that of non-septicemia group, and the time of premature rupture of membranes was earlier. The incidence of eating less, crying less, moving less, abdominal distention and skin blossom in septicemia group was higher than that in non-septicemia group. The levels of lactate, total bilirubin, C-reactive protein, IL-6 in umbilical cord blood and peripheral blood of septicemia group were higher than those of non-septicemia group. The ROC curve showed that the AUC of IL-6 in cord blood was 0.757, 95% CI (0.651-0.863), the threshold value was 17.6 pg/ml, the sensitivity was 56.4%, and the specificity was 94.3%. AUC of IL-6 in peripheral blood was 0.768, 95% CI (0.665-0.871), the threshold was 2.05pg/ml, the sensitivity was 69.2%, and the specificity was 83.0%. Conclusion: The levels of IL-6 in cord blood and peripheral blood were significantly higher in the early stage of sepsis, which may have clinical significance in the diagnosis of premature infants with early-onset sepsis. Conclusion: The level of IL-6 in cord blood increased significantly in the early stage of sepsis, which may have clinical significance in the diagnosis of premature infants with early-onset sepsis.
更新日期/Last Update: 2020-12-15