Abstract: Objective To investigate the clinical features, diagnosis, of myasthenia gravis (MG).Methods The clinical data of 52 patients with MG admitted from January 2015 to July 2018 in Department of Neurology, affiliated Hospital of Xuzhou Medical University were retrospectively analyzed..Using SPSS19.0 statistical analysis software for statistical analysis, the test level is 0. 05.The clinical data of a case of MOG antibody disease with epilepsy onset who were admitted into the Affiliated Hospital of Xuzhou Medical University in July 2018 were retrospectively analyzed. Results The main clinical manifestations of ocular muscle prolapse, diplopia, hoarseness or dysphagia, limb weakness, breathing effort.Positive rate of neostigmine test 100% (52/52).The positive rate of repetitive nerve stimulation was 90.7% (39/43).The positive rate of thymus CT was 52% (26/50).The positive rate of thyroid function was 28.9% (13/45), the abnormal rate of male was 10.5% (2/19), the abnormal rate of female was 42.3% (11/ 26).Conclusions There were more women in this group, most of whom were ophthalmic symptoms, type I and IIB were more common, the positive rate of neostigmine test and repetitive electrical stimulation was higher, and women were often accompanied with thymus and thyroid abnormalities. The detection of autoantibodies is helpful to guide rational diagnosis and treatment and to evaluate prognosis