[1]安华松,王建.Her-2/neu在结肠癌中的表达及其临床意义[J].徐州医科大学学报,2020,40(07):488-491.
 ex<x>pression of Her-2/neu in colon cancer and its clinical significance[J].Journal of Xuzhou Medical University,2020,40(07):488-491.
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Her-2/neu在结肠癌中的表达及其临床意义()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年07期
页码:
488-491
栏目:
出版日期:
2020-07-30

文章信息/Info

Title:
ex<x>pression of Her-2/neu in colon cancer and its clinical significance
作者:
安华松王建
文献标志码:
A
摘要:
目的 探讨HER-2/neu蛋白在人结肠癌组织中的表达及其临床病理特征,为临床诊断提供帮助。方法 采用免疫组织化学检测79例人结肠癌组织标本及对应的癌旁组织中HER-2/neu蛋白的表达。结果 癌组织中HER-2/neu的表达率明显高于癌旁组织组(P<0.05), HER-2/neu的阳性表达率在DukesC、D期和有淋巴结转移者明显高于DukesA、B期和无淋巴结转移者(P<0.05)。结论 HER-2/neu在结肠癌组织细胞中呈现高表达,提示可以作为结肠癌预后及靶向治疗的参考指标。
Abstract:
ob<x>jective To investigate the ex<x>pression of HER-2/neu protein in human colon cancer tissues and its relationship with clinical pathology. Methods Immunohistochemistry was used to detect the ex<x>pression of HER-2/neu protein in 79 specimens of human colon cancer tissues and adjacent tissues. Results The ex<x>pression of HER-2/neu was significantly higher in cancer tissues than in adjacent tissues ( P<0.05). The positive rate of HER-2/neu was significantly higher in Dukes C, D and lymph node me<x>tastasis than Dukes A and B Stage and no lymph node me<x>tastasis (P<0.05). Conclusion HER-2/neu is highly expressed in colon cancer tissues, suggesting that HER-2/neu can be used as a marker for the diagnosis and prognosis of colon cancer.
更新日期/Last Update: 2020-07-29