Abstract:
Objective: To investigate the risk factors of symptomaticVertebrobasilar dolichoectasia (VBD) for early intervention. Participants and methods: This study retrospectively collected patients with VBD from 2010-2018 and was classified into symptomatic VBD and non-symptomatic. The differences in clinical, imaging, and hematological findings between the two groups were analyzed. Results: A total of 184 patients were enrolled, including 143 (77.7%) in the symptom group and 41 (22.3%) in the non-symptomatic group. There were significant differences between symptomatic VBD and asymptomatic VBD in the diameter of basilar artery, the diameter difference of bilateral vertebral artery, the hypertension , neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),C-reactive protein(CRP),homocysteine(HCY), VAD(Vertebral artery dominance), the deviation(P<0.05)FLAIR vascular hyperintensity(P<0.05). Logistic regression analysis showed that the presence of VAD and FVH had significant effect on symptomatic VBD. Conclusion: Patients with symptomatic VBD were more likely to be associated with hypertension and hyperhomocysteinemia, and the related inflammatory markers NLR, PLR and CRP were significantly higher than those of non-symptomatic patients. VAD and FVH were risk factors of symptomatic VBD