[1]王新梅.活血化瘀方加减联合消癥散外敷对维吾尔族子宫内膜息肉患者ER、PR、Survivin和Bcl-2的影响及与术后复发的关系[J].徐州医科大学学报,2020,40(09):661-664.
 [J].Journal of Xuzhou Medical University,2020,40(09):661-664.
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活血化瘀方加减联合消癥散外敷对维吾尔族子宫内膜息肉患者ER、PR、Survivin和Bcl-2的影响及与术后复发的关系()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
661-664
栏目:
出版日期:
2020-09-25

文章信息/Info

作者:
王新梅
文献标志码:
A
摘要:
目的探讨活血化瘀方加减联合消癥散外敷对维吾尔族子宫内膜息肉患者ER、PR、Survivin和Bcl-2的影响及与术后复发的关系。方法:选取2016年3月-2017年12月来新疆维吾尔族自治区中医医院就诊诊断为血瘀型子宫内膜息肉的维吾尔族患者123例。采用盲法分为中药组62人,西药组61人。中药组术后口服活血化瘀方加减外敷消癥散,西药组术后口服妈富隆,疗程为3个月。比较两组治疗后中医症候积分、ER、PR、Survivin和Bcl-2表达以及术后一年子宫内膜息肉的复发率。结果:治疗后中医组的中医症候积分(5.7±1.53)低于西医组(7.2±1.82),差异有统计学意义,P<0.01。治疗后,中医组和西医组EP的表达无差异,而中医组PR的表达高于西医组。经qRT-PCR检验,中医组Survivin和Bcl-2 mRNA的相对表达量低于西医组,且中医组1年子宫内膜息肉复发率4.8%(3/62)低于西医组16.4%(10/61),差异有统计学意义。结论:活血化瘀方加减联合消癥散外敷能有效改善维吾尔族子宫息肉患者临床症状,可能通过纠正PR、Survivin和Bcl-2表达,从而降低子宫内膜息肉的复发。
Abstract:
Objective: To observe the effect of combined with Huoxue Huayu Recipe on ER, PR, Survivin and Bcl-2 in Uygur patients after hysteroscopic uterine polypectomy and its relationship with postoperative recurrence.Methods :From March 2016 to December 2017, 123 Uygur patients with bloody endometrial polyps were enrolled in the Xinjiang Uygur Autonomous Region Chinese Medicine Hospital. The blind method was divided into 62 Chinese medicine group and 61 western medicine group. After the operation, the Chinese medicine group was treated with oral administration of Huoxue Huayu Decoction plus external application Xiaozhengsan. The western medicine group was treated with oral Marvelon for 3 months. The Chinese medicine syndrome scores, ER, PR, Survivin and Bcl-2 expression and the recurrence rate of endometrial polyps after surgery were compared between the two groups. Result:After treatment, the Chinese medicine syndrome score of the Chinese medicine group (5.7±1.53) was lower than that of the Western medicine group (7.2±1.82), and the difference was uniform(P<0.01). After treatment, there was no difference in the expression of EP between the Chinese medicine group and the Western medicine group, while the expression of PR in the Chinese medicine group was higher than that of the Western medicine group. The relative expression of Survivin and Bcl-2 mRNA in the Chinese medicine group was lower than that in the Western medicine group by qRT-PCR. The recurrence rate of endometrial polyps in the Chinese medicine group was 4.8%, which was lower than that in the western medicine group (16.4%), the difference was statistically significant. Conclusion:Oral Huoxue Huayu Recipe plus orally and Xiaozhengsan can effectively improve the clinical symptoms of Uygur EP patients, possibly by correcting the expression of PR, Survivin and Bcl-2, thereby reducing the recurrence of endometrial polyps
更新日期/Last Update: 2020-10-12