Abstract:
Objective To investigate the effects of dexmedetomidine on desflurane-mediated sympathoexcitation.
Methods A total of 60 patients undergoing elective thoracic surgery, ASAⅠ-Ⅲ, were randomly divided into two groups: desflurane group (Group C) and dexmedetomidine combined with desflurane group (Group D). Patients in Group C were treated with 0.1 ml/kg of normal saline within 10 min before induction of anesthesia, then the dose was changed to 0.05 ml/(kg·h) of normal saline. Patients in Group D were treated with 0.5 μg/kg dexmedetomidine within 10 min before induction of anesthesia, then the dose was changed to 0.5 μg/(kg·h) of dexmedetomidine. Mean arterial pressure (MAP), heart rate (HR), heart rate variability (HRV), levels of plasma norepinephrine (NE) and epinephrine (E) were recorded after entering the operating room (T
0) and at 1 min, 2 min, 3 min, 4 min, 5 min (T
1, T
2, T
3, T
4, T
5)after the concentration of desflurane reaching 1.0 minimum alveolar concentration (MAC).
Results The MAP, HR, ratio of low frequency to high frequency (LF/HF), levels of plasma E and NE from T
1 to T
5 in Group C were higher than those of the T
0 time point (
P<0.05). The differences of MAP, HR, LF/HF, levels of plasma E and NE from T
1 to T
5 in Group D were not statistically significant (
P>0.05). The differences of MAP, HR, LF/HF, levels of plasma E and NE at T
0 time point were not statistically significant between Group C and Group D (
P>0.05), while the differences were statistically significant between the two groups at T
3 and T
4 time points (
P<0.05). The differences of HR, LF/HF, levels of plasma E and NE at T
5 was statistically significant between the two groups (
P<0.05).
Conclusions Dexmedetomidine can inhibit desflurane-mediated sympathoexcitation, which is beneficial for maintaining perioperative hemodynamic stability and reducing perioperative complications.