Abstract: Objective: To analyze the application effect and value of failure mode and effect analysis in the re-engineering of critically ill patients in emergency department. Methods: A retrospective analysis of the clinical data of 600 patients who were transferred from our hospital from January 2017 to December 2018, and 289 patients who were transferred by traditional methods from January 2017 to December 2017 were included in the control group. 311 patients who were optimally transported under the Failure Mode and Effect Analysis (FMEA) from January 2018 to December 2018 were included in the observation group. The differences in transit time, adverse events during transit, and patient satisfaction were compared. Results: The incidence of adverse events in the two groups was significantly lower than that in the control group (P < 0.05), and the transit time in the observation group was significantly shorter than that in the control group (P < 0.05), and the nursing satisfaction rate in the two groups was significantly higher than that in the control group (P < 0.05). Conclusion: The application of failure mode and effect analysis in emergency critical patients transfer process reengineering can effectively prevent adverse events, shorten hospital transfer time, improve patients’satisfaction with nursing services, and has significant clinical application value.