Abstract: Objective To preliminarily explore the effectiveness and suitability of community cardiac rehabilitation based on integrated traditional Chinese and Western medicine under the guidance of third-grade hospitals for patients who have undergone percutaneous coronary intervention (PCI) for coronary heart disease (CHD).Methods Ninety-five patients initially treated with PCI for CHD were randomly assigned to the conventional treatment group (N=46) or cardiac rehabilitation group (N=49). The conventional treatment group received conventional treatment for secondary prevention of CHD; the cardiac rehabilitation group received community cardiac rehabilitation based on integrated traditional Chinese and Western medicine under the guidance of third-grade hospitals; both groups were followed up for 6 months. Six-Minute Walk Distance （6MWD）, left ventricular ejection fraction (LVEF）, N-terminal pro b-type natriuretic peptide （NT-proBNP）PHQ-9 score, GAD-7 score, incidence of major adverse cardiovascular events (MACEs）, as well as the rate of readmission due to chest discomfort and anxiety, etc., were collected from patients in both groups at baseline and at 6 months of intervention.Results At 6 months of intervention, 6MWD was significantly longer, and NT-proBNP was significantly lower in the rehabilitation group than in the control group, with statistically significant differences（t=4.710，t=2.031，P<0.05）. At 6 months of intervention, PHQ-9 score decreased significantly from baseline in the rehabilitation group, with statistically significant difference（t=2.910，P<0.05）, while there was no statistically significant change from baseline in PHQ-9 score in the control group（t=1.611，P>0.05）. At 6 months of intervention, the incidences of overall MACEs, myocardial infarction, and repeat revascularization increased in the control group compared to the rehabilitation group; however the differences were not statistically significant (all P>0.05) ; the readmission rate was lower in the rehabilitation group than in the control group, with statistically significant difference（χ2 =4.146，P<0.05）. No accidental injuries from exercise or exercise-related cardiovascular events were reported throughout the rehabilitation process. Conclusion For patients who have undergone PCI for CHD, community cardiac rehabilitation based on integrated traditional Chinese and Western medicine under the guidance of third-grade hospitals is safe, effective and feasible, warranting further observational studies.