Abstract: ob＜x＞jective By measuring the levels of serum somatostatin, IGF-1 and IGFBP-3 indexes in children with idiopathic short stature, to study the correlation between Helicobacter pylori (Hp) infection and idiopathic short stature, and the possible mechanisms of influence . Methods 150 cases (male 72, female 78) of idiopathic short stature children which divided into early school age、school age（early stage） and puberty were selected from who had come to our hospital from 2017 to 2019, none of them had endocrine or chronic organic diseases. The children also were divided into Hp infected group and non-infection group by the C13 breath test on an empty stomach. Compare Hp infection rate and height, weight, body mass index (BMI), hemoglobin and albumin levels between these two groups in there stages, and measure the levels of somatostain, IGF-1 and IGFBP-3 in serum. Results With the increase of age the infection rate of Hp gradually increases. In the school-age (early stage ),the infection rate of Hp has increased to more than 50%. Compared with the Hp infected group, the height and hemoglobin index levels of children in HP non-infection group were all higher in three periods, with statistically significant differences (P＜0.05), while there was no significant difference in weight, BMI and albumin. Compared with the non-infection group, the serum somatostatin levels of the children in the Hp infected group were all lower in three periods, with statistically significant differences (P＜0.05). However, the level of IGF-1 and IGFBP-3 have no statistics significance in these two groups. Conclusion Hp infection could decrease the level of serum somatostatin, but it dose not affect the level of IGF-1 and IGFBP-3. The diminution of serum somatostatin may have effects on the height of idopathic short stature children