[1]周雨林,沈栋林*,王军,等.Hp感染对特发性矮身材儿童血清生长抑素、IGF-1及IGFBP-3水平的影响[J].徐州医科大学学报,2022,42(03):204-206.[doi:10.3969/j.issn.2096-3882.2022.03.009]
 Analysis of the correlation between the levels of serum somatostatin, IGF-1 and IGFBP-3 indexes and Helicobacter pylori infection in idiopathic short stature children[J].Journal of Xuzhou Medical University,2022,42(03):204-206.[doi:10.3969/j.issn.2096-3882.2022.03.009]
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Hp感染对特发性矮身材儿童血清生长抑素、IGF-1及IGFBP-3水平的影响()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
42
期数:
2022年03期
页码:
204-206
栏目:
出版日期:
2022-03-25

文章信息/Info

Title:
Analysis of the correlation between the levels of serum somatostatin, IGF-1 and IGFBP-3 indexes and Helicobacter pylori infection in idiopathic short stature children
作者:
周雨林1沈栋林2*王军2高莉莉2赵彤2
1. 徐州医科大学研究生院,江苏徐州221004;2.徐州医科大学附属医院儿科,江苏徐州221002
关键词:
特发性矮身材幽门螺杆菌生长抑素胰岛素样生长因子-1胰岛素样生长因子结合蛋白-3
分类号:
R725.7
DOI:
10.3969/j.issn.2096-3882.2022.03.009
文献标志码:
A
摘要:
目的 通过测定特发性矮小儿童血清生长抑素、血清胰岛素样生长因子-1(IGF-1)以及胰岛素样生长因子结合蛋白-3(IGFBP-3)的指标水平,研究其与幽门螺杆菌(Hp)感染的相关性,从而探讨Hp感染与特发性矮小的关系及可能影响机制。 方法 收集2017年至2019年来我院就诊的特发性矮小儿童150例,男72例,女78例,将其分为学龄前期、学龄期(初期)、青春期三个时期,所选儿童均无内分泌及慢性器质性疾病。在空腹状态下行C13呼气试验,阳性者为Hp感染组,阴性者为Hp非感染组,比较三个时期幽门螺杆菌感染率以及三个时期Hp感染组与非感染组儿童身高、体重、BMI、血红蛋白、白蛋白的水平,并测定血清中生长抑素、IGF-1、IGFBP-3的指标水平。结果 随着年龄增长Hp感染率逐渐增高,在学龄期(初期),Hp感染率已上升到50%以上;与Hp感染组相比,Hp非感染组三个时期的儿童身高及血红蛋白指标水平均较高,差异有统计学意义(P<0.05),而体重、BMI、白蛋白水平无明显差异;与Hp非感染组相比,Hp感染组三个时期的患儿血清生长抑素水平均较低,差异有统计学意义(P<0.05);而血清IGF-1及IGFBP-3水平在两组之间比较差异无统计学意义(P>0.05)。结论 Hp感染可使血清生长抑素水平降低,但不影响特发性矮小儿童血清IGF-1、IGFBP-3的水平;而体内血清生长抑素水平的降低可能对特发性矮小儿童身高产生一定的影响。
Abstract:
ob<x>jective By measuring the levels of serum somatostatin, IGF-1 and IGFBP-3 indexes in children with idiopathic short stature, to study the correlation between Helicobacter pylori (Hp) infection and idiopathic short stature, and the possible mechanisms of influence . Methods 150 cases (male 72, female 78) of idiopathic short stature children which divided into early school age、school age(early stage) and puberty were selected from who had come to our hospital from 2017 to 2019, none of them had endocrine or chronic organic diseases. The children also were divided into Hp infected group and non-infection group by the C13 breath test on an empty stomach. Compare Hp infection rate and height, weight, body mass index (BMI), hemoglobin and albumin levels between these two groups in there stages, and measure the levels of somatostain, IGF-1 and IGFBP-3 in serum. Results With the increase of age the infection rate of Hp gradually increases. In the school-age (early stage ),the infection rate of Hp has increased to more than 50%. Compared with the Hp infected group, the height and hemoglobin index levels of children in HP non-infection group were all higher in three periods, with statistically significant differences (P<0.05), while there was no significant difference in weight, BMI and albumin. Compared with the non-infection group, the serum somatostatin levels of the children in the Hp infected group were all lower in three periods, with statistically significant differences (P<0.05). However, the level of IGF-1 and IGFBP-3 have no statistics significance in these two groups. Conclusion Hp infection could decrease the level of serum somatostatin, but it dose not affect the level of IGF-1 and IGFBP-3. The diminution of serum somatostatin may have effects on the height of idopathic short stature children

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更新日期/Last Update: 2022-05-09