[1]王华姨,高莉莉,赵彤,等.单用rhGH与GnRHa及联合治疗对于青春期早发育的特发性矮身材儿童的临床研究[J].徐州医科大学学报,2020,40(09):699-702.
　The clinical study of rhGH and GnRHa alone and their combination in the treatment of idiopathic short stature children with early puberty[J].Journal of Xuzhou Medical University,2020,40(09):699-702.
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单用rhGH与GnRHa及联合治疗对于青春期早发育的特发性矮身材儿童的临床研究()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
699-702
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
The clinical study of rhGH and GnRHa alone and their combination in the treatment of idiopathic short stature children with early puberty
作者:
王华姨; 高莉莉; 赵彤; 沈栋林
文献标志码:
A
摘要:
目的 旨在分析单用重组人生长激素（rhGH）与促性腺激素释放激素类似物（GnRHa）及二者联合使用治疗青春期早发育的特发性矮身材（ISS）患儿的近期疗效与安全性。方法 选取2017年9月至2019年6月我院收治的60例青春期早发育的特发性矮身材患儿作为本次研究对象，随机分为A组（重组人生长激素 rhGH）、B组（促性腺激素释放激素类似物 GnRHa）和C组（重组人生长激素联合促性腺激素释放激素类似物）3组，每隔3个月随诊一次，监测身高、体重、预测终身高（PAH）、IGF-1、LH、FSH、E2或T、子宫卵巢或睾丸大小、空腹血糖、甲状腺功能、肝功能等指标的水平，6个月测一次骨龄。结果 随访1年后，3组患儿身高、骨龄、预测终身高与治疗前比较，差异均有统计学意义（P<0.05），联合治疗组患儿生长速度高于单一治疗组，差异有统计学意义（P<0.05）。治疗后3组患儿血糖、甲状腺功能及肝酶与治疗前对比差异无统计学意义P>（0.05）。结论 单用rhGH与GnRHa及联合治疗后，患儿身高均较治疗前显著增加，联合治疗组效果优于单一治疗组，且3组治疗前后无明显不良反应。
Abstract:
ob＜x＞jective To analyze the short-term efficacy and safety of recombinant human growth hormone (rhGH), gonadotropin-releasing hormone analogue (GnRHa) alone and their combination in the treatment of early puberty children with idiopathic short stature (ISS).Methods From September 2017 to June 2019, 60 children with idiopathic short stature were randomly divided into three groups: group A (recombinant human growth hormone rhGH), group B (GnRHa) and group C (recombinant human growth hormone combined with gonadotropin-releasing hormone analogue). They were followed up every three months and supervised Height, weight, predicted final height (PAH), IGF-1, LH, FSH, E2 or T, uterus, ovary or testicle size, fasting blood glucose, thyroid function, liver function and other indicators were measured. Bone age was measured once every six months.Results After 1 half year follow-up, the height, bone age and predicted final height of the three groups were significantly different from those before treatment (P < 0.05), and the growth rate of the combined treatment group was higher than that of the single treatment group (P < 0.05). There was no significant difference in blood glucose, thyroid function and liver enzyme between the three groups (P > 0.05).Conclusion After rhGH and GnRHa alone and combined treatment, the height of children increased significantly, the effect of combined treatment group was better than that of single treatment group, and there was no significant adverse reaction in three groups before and after treatment.
更新日期/Last Update: 2020-10-12