[1]刘金琦.APOE基因多态性与经皮冠状动脉介入治疗后支架内再狭窄的相关性研究[J].徐州医科大学学报,2020,40(07):482-487.
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APOE基因多态性与经皮冠状动脉介入治疗后支架内再狭窄的相关性研究()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年07期
页码:
482-487
栏目:
出版日期:
2020-07-30

文章信息/Info

Title:
Association of APOE gene polymorphism with in-stent restenosis in patients with coronary heart disease after PCI
作者:
刘金琦
文献标志码:
A
摘要:
摘要:目的 探讨载脂蛋白E(APOE)基因多态性与冠心病(CHD)患者行经皮冠状动脉介入治疗(PCI)后支架内再狭窄的相关性。方法 入选2016年1月至2018年10月期间在徐州医科大学附属医院接受冠状动脉药物洗脱支架(DES)置入术并在12-36个月内复查血管造影的冠心病患者172例。根据冠脉造影结果分为再狭窄(ISR)组和非再狭窄(non-ISR)组。单因素分析比较ISR组与non-ISR组的一般资料、造影特征、服药情况、血液学指标、APOE基因型。以单因素分析中有统计学差异(P<0.05)的指标为自变量,以ISR为因变量,进行二元logistic回归分析,研究ISR的独立危险因素。结果 单因素分析显示ISR组LDL-C、HbAlc水平、E3/4基因型频率、支架串联长度、支架数均高于non-ISR组(P<0.05),而最小支架直径小于non-ISR组(P<0.05)。携带E3/E4基因型患者血清LDL-C明显升高。Logistic回归分析显示E3/4基因型、HbAlc、LDL-C水平为支架内再狭窄独立危险因素。
Abstract:
Abstract:ob<x>jective To investigate the association between apolipoprotein E (APOE) gene polymorphism and in-stent restenosis(ISR)in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods A total of 172 patients with coronary heart disease who underwent drug-eluting coronary stent implantation in the affiliated Hospital of Xuzhou Medical University from January 2016 to October 2018 and were reexamined by angiography within 36 months were enrolled in this study.According to the results of coronary angiography,the patients were divided into ISR group and non-ISR group.Univariate analysis was used to compare the general data,angiographic features,medication,hematological parameters and APOE genotypes between the ISR group and the non-ISR group.The independent risk factors of ISR were studied by logistic stepwise regression analysis with the independent variable and ISR as the dependent variable in univariate analysis.Results Univariate analysis showed that the levels of LDL-C and HbAlc,the frequency of genotype E3/4,the stent length and the number of stents in ISR group were higher than those in non-ISR group,while the stent diameter was smaller than that in non-ISR group (P<0.05).The level of serum LDL-C in patients with E3/E4 genotype was sig-nificantly higher than that in controls.Logistic regression analysis showed that E3/4 genotype,HbAlc and LDL-C levels were independent risk factors for in-stent restenosis.Conclusion Polymorphism of apolipoprotein E gene is associated with in-stent restenosis,and E3/4 genotype is an independent risk factor for ISR.Further genetic studies can identify risk genotypes,which is helpful for early prediction and identification of high-risk patients with ISR.
更新日期/Last Update: 2020-07-29