[1]张丹,李胜开,尹忠诚.贫血程度与ANCA相关性血管炎伴肾损害患者的相关性分析[J].徐州医科大学学报,2020,40(07):496-501.
　Analysis of the relationship between the degree of anemia and ANCA-associated vasculitis with renal damage[J].Journal of Xuzhou Medical University,2020,40(07):496-501.
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贫血程度与ANCA相关性血管炎伴肾损害患者的相关性分析()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年07期
页码:
496-501
栏目:
出版日期:
2020-07-30

文章信息/Info

Title:
Analysis of the relationship between the degree of anemia and ANCA-associated vasculitis with renal damage
作者:
张丹; 李胜开; 尹忠诚
文献标志码:
A
摘要:
目的 探讨贫血程度与抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）伴肾损害患者的相关性。方法 回顾性的分析2013年1月1日至2019年6月30日在徐州医科大学附属医院确诊并首发的120例ANCA相关性血管炎（AAV）伴肾损害的患者的临床资料，入选患者均伴有贫血（贫血的标准：男性Hb＜120g/L，女性＜110g/L）。将其按贫血程度分为轻度、中度、重度，即Hb≥90g/L组,60 g/L≤Hb＜90 g/L组，Hb＜60g/L组，比较三组患者的临床特点，分析不同贫血程度水平与临床指标的相关性，分析与患者及其肾脏预后的相关性。结果 不同贫血程度患者的前驱期持续时间[发病到确诊时间]、血沉（ESR）、C反应蛋白（CRP）、血清白蛋白（Alb）、血肌酐(Scr) 、肾小球滤过率（eGFR）、尿蛋白定量(g/24h)，均有统计学意义（P＜0.05）。患者Hb水平与前驱期持续时间、ESR、CRP、Scr、尿蛋白（g/24h）水平呈负相关(P＜0.05)，与Alb和eGFR水平呈正相关(P＜0.05)。不同贫血程度患者及其肾脏存活率具有统计学意义（P＜0.01 ）。结论 ANCA相关性血管炎（AAV）伴肾损害患者常常伴有贫血，贫血程度越重，肾功能越差，患者死亡率越高，其肾脏存活率越低。
Abstract:
ob＜x＞jective To explore the relationship between the degree of anemia and antineutrophil cytoplasmic antibody ((ANCA)) associated vasculitis (AAV) with renal damage.Methods The clinical data of 120 patients with ANCA-associated vasculitis with renal damage diagnosed and first diagnosed in the affiliated Hospital of Xuzhou Medical University from January 1, 2013 to June 30, 2019 were retrospectively analyzed. All the selected patients were associated with anemia.（Anemia criteria: male Hb < 120g/L, female Hb < 110g/L）. According to the degree of anemia, the patients were divided into mild, moderate and severe groups, that is, Hb ≥ 90g/L group, 60g/ L ≤ HB < 90g/L group and Hb < 60g/L group. The clinical characteristics of the three groups were compared, and the correlation between different anemia levels and clinical indexes was analyzed. The correlation with the prognosis of the patients and their kidneys was analyzed.Results There were significant differences in prodromal phase [time from onset to diagnosis], erythrocyte sedimentation rate ((ESR)), C-reactive protein (CRP), serum albumin (Alb), serum creatinine (Scr), glomerular filtration rate ((eGFR)), and urinary protein quantity (g/24 h) in patients with different degrees of anemia(P < 0.05). The level of Hb was negatively correlated with the duration of prodromal phase, ESR, CRP, Scr and urinary protein (g/24 h) (P < 0.05), but positively correlated with the levels of Alb and eGFR (P < 0.05).There was statistical significance in patients with different degrees of anemia and their renal survival rate (P < 0.01).Conclusions Patients with ANCA-associated vasculitis and (AAV) with renal damage are often accompanied by anemia，the more severe the anemia, the worse the renal function, the higher the mortality and the lower the renal survival rate.
更新日期/Last Update: 2020-07-29