Abstract: ob＜x＞jective To explore the relationship between the degree of anemia and antineutrophil cytoplasmic antibody ((ANCA)) associated vasculitis (AAV) with renal damage.Methods The clinical data of 120 patients with ANCA-associated vasculitis with renal damage diagnosed and first diagnosed in the affiliated Hospital of Xuzhou Medical University from January 1, 2013 to June 30, 2019 were retrospectively analyzed. All the selected patients were associated with anemia.（Anemia criteria: male Hb < 120g/L, female Hb < 110g/L）. According to the degree of anemia, the patients were divided into mild, moderate and severe groups, that is, Hb ≥ 90g/L group, 60g/ L ≤ HB < 90g/L group and Hb < 60g/L group. The clinical characteristics of the three groups were compared, and the correlation between different anemia levels and clinical indexes was analyzed. The correlation with the prognosis of the patients and their kidneys was analyzed.Results There were significant differences in prodromal phase time from onset to diagnosis, erythrocyte sedimentation rate ((ESR)), C-reactive protein (CRP), serum albumin (Alb), serum creatinine (Scr), glomerular filtration rate ((eGFR)), and urinary protein quantity (g/24 h) in patients with different degrees of anemia(P < 0.05). The level of Hb was negatively correlated with the duration of prodromal phase, ESR, CRP, Scr and urinary protein (g/24 h) (P < 0.05), but positively correlated with the levels of Alb and eGFR (P < 0.05).There was statistical significance in patients with different degrees of anemia and their renal survival rate (P < 0.01).Conclusions Patients with ANCA-associated vasculitis and (AAV) with renal damage are often accompanied by anemia，the more severe the anemia, the worse the renal function, the higher the mortality and the lower the renal survival rate.