Abstract:
objective Synovial sarcoma (SS) is a mesenchymal malignant tumor. Although it is recognized as a translocation-related sarcoma, we still know little about the molecular mechanism of SS metastasis. The purpose of this study is to analyze metastatic SS and non-metastatic SS gene chips to identify core genes related to SS metastasis and prognosis. Methods First, download the mRNA expression profile database GSE40025/GPL6480 chip data set. Then, differentially expressed genes (DEGs) were screened between metastatic SS samples and non-metastatic SS samples in the microarray. Functional annotation of DEGs was carried out to construct a protein-protein interaction (PPI) network to identify the key pathways and core genes related to SS metastasis and prognosis. Finally, we use The Cancer Genome Atlas (TCGA) database to analyze the survival of core genes. Results Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction ,PI3K-Akt signaling pathway and Th17 cell differentiation may be the key signal pathways involved in SS metastasis. In addition, we found that CDK1, IL6, KIF11, KIF20A, CCNA2, AURKA, CENPE, KIF4A and CCNB2 are the 9 core genes most likely to participate in SS metastasis and related to survival, and they may become therapeutic targets and prognostic markers for SS. Conclusion The metastasis and development of SS are closely related to the complexity of chromosomes. In this study, the signal pathways and core genes closely related to SS metastasis were identified for the first time, providing new therapeutic targets and prognostic markers for SS