[1]王维奇.卵巢癌组织中CTHRC1、VEGF表达及临床意义[J].徐州医科大学学报,2020,40(09):640-644.
 ex<x>pression and clinical significance of CTHRC1 and VEGF in ovarian cancer[J].Journal of Xuzhou Medical University,2020,40(09):640-644.
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卵巢癌组织中CTHRC1、VEGF表达及临床意义()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
640-644
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
ex<x>pression and clinical significance of CTHRC1 and VEGF in ovarian cancer
作者:
王维奇
文献标志码:
A
摘要:
目的 探讨卵巢癌组织中三螺旋重复胶原蛋白1(CTHRC1)、血管内皮生长因子(VEGF)表达及临床意义。方法 选取2012年1月至2017年1月徐州市中心医院保存的卵巢癌组织标本86例,同时选取正常卵巢组织80例,采用免疫组化染色法检测CTHRC1、VEGF表达。结果 卵巢癌组织CTHRC1和VEGF蛋白阳性表达率分别为67.44%和69.77%,明显高于正常卵巢组织(P<0.05);FIGO分期Ⅲ~Ⅳ期、病理分级G3、有淋巴结转移患者CTHRC1蛋白阳性表达率分别为96.43%、80.36%和90.32%,明显高于FIGO分期Ⅰ~Ⅱ、病理分级G1+G2、无淋巴结转移患者(P<0.05);FIGO分期Ⅲ~Ⅳ期、有淋巴结转移患者VEGF蛋白阳性表达率分别为85.71%和90.32%,明显高于FIGO分期Ⅰ~Ⅱ、无淋巴结转移患者(P<0.05);卵巢癌患者CTHRC1和VEGF蛋白表达呈正相关(rs=0.515,P<0.05)。结论 卵巢癌组织中CTHRC1、VEGF表达明显上调,可能与患者FIGO分期、病理分级以及淋巴结转移有关,同时CTHRC1和VEGF表达呈正相关,值得进一步研究。
Abstract:
ob<x>jective: To investigate the ex<x>pression of triple helix repeat collagen 1 (CTHRC1) and vascular endothelial growth factor (VEGF) in ovarian cancer and its clinical significance. Methods: From January 2012 to January 2017, 86 ovarian cancer specimens and 80 normal ovarian tissues were selected, the ex<x>pressions of CTHRC1 and VEGF were detected by immunohistochemical staining. Results: The positive rates of CTHRC1 and VEGF protein in ovarian cancer tissues were 67.44% and 69.77% respectively, which were significantly higher than those in normal ovarian tissues (p < 0.05); The positive ex<x>pression rates of CTHRC1 protein in patients with FIGO stage III-IV, pathological grade G3 and lymph node me<x>tastasis were 96.43%, 80.36% and 90.32% respectively, which were significantly higher than those in patients with FIGO stage I-II, pathological grade G1+G2 and no lymph node me<x>tastasis (p < 0.05); The positive ex<x>pression rate of VEGF protein in patients with FIGO stage III-IV and lymph node me<x>tastasis were 85.71% and 90.32% respectively, which were significantly higher than that in patients with stage I-II FIGO and without lymph node me<x>tastasis (p < 0.05); The ex<x>pression of CTHRC1 and VEGF protein in ovarian cancer patients was positively correlated (rs=0.515, P < 0.05). Conclusion: The ex<x>pression of CTHRC1 and VEGF are up-regulated in ovarian cancer tissues, which may be related to FIGO stage, pathological grade and lymph node me<x>tastasis, and the ex<x>pression of CTHRC1 and VEGF are positively correlated, is worth further study
更新日期/Last Update: 2020-10-12