[1]胡丹,齐共健,刘晓鸣.GFAP、MBP、S100β蛋白在脓毒症相关性脑病早期识别及病情评估中的临床应用价值[J].徐州医科大学学报,2020,40(09):691-694.
 Clinical Application Value of GFAP, MBP and S100 protein in early identification and condition evaluation of sepsis associated encephalopathy[J].Journal of Xuzhou Medical University,2020,40(09):691-694.
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GFAP、MBP、S100β蛋白在脓毒症相关性脑病早期识别及病情评估中的临床应用价值()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
691-694
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
Clinical Application Value of GFAP, MBP and S100 protein in early identification and condition evaluation of sepsis associated encephalopathy
作者:
胡丹齐共健刘晓鸣
文献标志码:
A
摘要:
目的 检测脓毒症相关性脑病(Sepsis associated encephalopathy ,SAE)患儿血清中胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、髓鞘碱性蛋白(myelin basic protein,MBP)、S100β蛋白水平的变化,探索其在SAE早期识别及病情严重程度评估中的价值。方法 选择2018年1月至2020年1月入住徐州医科大学附属徐州儿童医院PICU 80例脓毒血症患儿为研究对象,其中SAE组40例,脓毒症未合并脑病(non-SAE)组40例,另选择40例健康体检患儿为对照组。对SAE组患儿进行格拉斯哥昏迷评分(Glasgow Coma Scale ,GCS)、全面无反应性量表(Full Outline of UnResponsiveness ,FOUR)评分。应用ELISA法,检测患儿治疗前(入住ICU 1小时内)、治疗后3天及5天血清中GFAP、MBP、S100β蛋白水平的变化。根据患儿意识障碍程度将 SAE组分为轻(意识模糊组)和重(昏迷组)两个组别,比较入住ICU1小时内血清GFAP、MBP、S100β蛋白水平在两组别之间的差异。并观察 GFAP、MBP、S100β蛋白水平与格拉斯哥昏迷评分(GCS)、全面无反应性量表(FOUR)是否存在相关性。结果 1、SAE 组入住ICU1小时内血清GFAP、MBP、S100β蛋白水平较non-SAE组及对照组明显升高(P<0.05),SAE患儿中昏迷组血清GFAP、MBP、S100β蛋白水平较意识模糊组明显升高(P<0.05)。2、SAE组治疗后3天血清GFAP、MBP、S100β蛋白水平较non-SAE组高(P <0.05)。3、治疗后5天SAE组血清中GFAP、MBP、S100β蛋白的水平较non-SAE无显著性差异(P>0.05)。GFAP、MBP、S100β蛋白水平与格拉斯哥昏迷评分(GCS)、全面无反应性量表(FOUR)呈负相关。结论 血清GFAP、MBP、S100β蛋白有助于SAE的早期识别,对SAE病情严重程度的评估具有积极的意义。
Abstract:
ob<x>jective To measure the change of the level of glial fibrillary acidic protein(GFAP) ,myelin basic protein(MBP),S100β protein in serum with Sepsis associated encephalopathy,and to study its clinical application value in the early recognition and severity evaluation of sepsis associated encephalopathy. Methods According to the diagnostic criteria of sepsis(In line with the 2015 edition of the diagnostic criteria for sepsis in children), PICU 80 children with sepsis admitted to Xuzhou Children’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’s Hospital,xuzhou Medical University from January 2018 to January 2020 were selected as the study subjects. They were divided into the SAE group (40 cases) , the Non-SAE group (40 cases). and Forty healthy children were selected as the control group. Children in the SAE group were assessed with Glasgow Coma Scale (GCS) and Full Outline of UnResponsiveness (FOUR) . The changes of serum GFAP, MBP and S100 protein levels in children into the ICU within 1 hour, 3 days after treatment and 5 days after treatment were detected by ELISA and compared. The SAE group was divided into two groups according to the degree of consciousness disturbance of the children, light (fuzzy consciousness group) and heavy (coma group), serum GFAP, MBP and S100 protein levels were compared between the two groups. The correlation between GFAP, MBP, S100 levels and Glasgow coma score (GCS) and total nonreactivity scale (FOUR) was observed. Results The serum levels of GFAP, MBP and S100 protein in the SAE group were significantly higher than those in the non-SAE group and the control group within 1 hour after into the ICU (P <0.05). The serum levels of GFAP, MBP and S100 in the coma group were significantly higher than those in the fuzzy consciousness group (P <0.05); The serum levels of GFAP, MBP and S100 protein in the SAE group were higher than those in the non-SAE group 3 days after treatment (P <0.05); The serum levels of GFAP, MBP and S100 protein in SAE group at 5 days after treatment showed no significant difference compared with non-SAE(P >0.05). The levels of GFAP, MBP and S100 protein were negatively correlated with the Glasgow coma score (GCS) and the overall nonreactivity scale (FOUR). Conclusion Serum GFAP, MBP, S100 protein help in the early identification of SAE, The assessment of the severity of SAE was positive, For evaluation of the severity of disease has the positive significance.
更新日期/Last Update: 2020-10-12