[1]潘兆军,杨利丽,卢秀丽,等.缬更昔洛韦治疗新生儿先天性巨细胞病毒感染临床观察[J].徐州医科大学学报,2020,40(09):682-686.
　Oral Valganciclovir for Symptomatic Congenital Cytomegalovirus Infection in Newborns[J].Journal of Xuzhou Medical University,2020,40(09):682-686.
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缬更昔洛韦治疗新生儿先天性巨细胞病毒感染临床观察()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
682-686
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
Oral Valganciclovir for Symptomatic Congenital Cytomegalovirus Infection in Newborns
作者:
潘兆军; 杨利丽; 卢秀丽; 王静; 王军
文献标志码:
A
摘要:
目的 观察缬更昔洛韦( VGCV) 治疗 先天性巨细胞病毒( CMV) 感染患儿的疗效及安全性。方法 先天性CMV感染病例分为VGCV和更昔洛韦（GCV）治疗组。VGCV治疗组口服VGCV 16mg/kg，q12h；GCV治疗组予以静脉注射GCV 6mg/kg，q12h，疗程均为6周。比较两组血和尿CMV-DNA PCR、血清CMV-IgM、 肝脾肿大、高胆红素血症、头颅MRI、脉络膜视网膜炎、脑干听觉诱发电位、中性粒细胞减少症、医院感染、PICC置管、住院天数、住院费用。结果 VGCV组和GCV组对新生儿先天性巨细胞病毒感染具有相似的疗效，治疗过程中中性粒细胞减少症发生相似。VGCV组住院时间短，费用低，医院感染率和PICC置管率均明显低于GCV组。 结论 口服缬更昔洛韦与静脉注射更昔洛韦治疗新生儿先天性巨细胞病毒感染疗效及不良反应类似，并可缩短住院时间，降低医疗费用、中心静脉置管及医院感染发生率。
Abstract:
ob＜x＞jective To observe the efficacy and safety of oral valganciclovir (VGCV) in newborns with congenital cytomegalovirus infection. Methods The newborns with congenital CMV infection were divided into VGCV and GCV treatment groups. The VGCV treatment group cases were treated with oral valganciclovir ,16mg/kg, q12h; the GCV treatment group cases were intravenously injected with GCV, 6mg/kg, q12h. The course of treatment is 6 weeks. Blood and urine CMV-DNA PCR, serum CMV-IgM, hepatosplenomegaly, hyperbilirubinemia, cranial MRI, choroidal retinitis, brainstem auditory evoked potential, neutropenia were examined and compared between two groups. Nosocomial infection, PICC placement, length of stay, and hospitalization costs were compared between the two groups of patients. Results The VGCV group had similar effect to neonatal congenital cytomegalovirus infection, and the neutropenia occurred similarly during the treatment. VGCV group had significantly shorter hospital stay and lower cost. Hospital infection rate and PICC placement rate were lower than GCV group. Conclusion Oral valganciclovir is similar to intravenous ganciclovir in the treatment of neonatal congenital cytomegalovirus infection, and has similar adverse effects. It can shorten the length of hospital stay, reduce medical costs, the incidence of central venous catheterization and nosocomial infection.
更新日期/Last Update: 2020-10-12