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    南京地区健康儿童血清维生素A、D、E水平分析

    Analysis of serum vitamin A, D and E levels of healthy children in Nanjing

    • 摘要: 目的 了解南京地区健康儿童血清脂溶性维生素A、D、E的水平。方法 收集南京医科大学第二附属医院健康儿童的体检资料并分组,每例儿童血清维生素A(VA)、维生素E(VE)水平采用反相高效液相色谱荧光检测法测定,每例儿童血清25羟维生素D(25-OH-VD)水平采用液相串联质谱法测定,分析各年龄组维生素A、D、E的水平。结果 健康体检儿童共2 151例,血清VA平均水平为(0.32±0.08)mg/L,≤1岁组VA水平最低(0.29±0.075)mg/L;所有受检儿童低水平VA检出率为37.09%,≤1岁组检出率最高(54.19%);血清25-OH-VD平均水平(34.24±9.31)μg/L,>6岁组25-OH-VD水平最低(25.58±8.67)μg/L;所有受检者低水平25-OH-VD检出率为33.56%(722/2 151),>6岁组检出率最高(77.89%);血清VE平均水平为(10.69±3.57)mg/L,>6岁组最低(8.59±1.96)mg/L;所有受检者低水平VE检出率为5.57%(120/2 151),>6岁组检出率最高(20%)。男童血清25-OH-VD和VE水平低于女童。6岁<年龄≤14岁组的男童血清25-OH-VD水平比女童低 (P=0.043)。≤1岁组和1岁<年龄≤3岁组男童血清VE的水平低于同年龄段女童(P<0.05)。结论 南京地区1岁以下儿童VA水平最低,25-OH-VD、VE水平则随儿童年龄增长,逐渐降低。

       

      Abstract: Objective To investigate the levels of serum soluble vitamins A, D, and E in healthy children in Nanjing. Methods The data of physical examination of healthy children in the Second Affiliated Hospital of Nanjing Medical University were collected and grouped. The levels of serum vitamin A and vitamin E of each child were determined by reversed-phase high-performance liquid chromatography fluorescence detection. The levels of serum 25-hydroxy vitamin D (25(OH)D) were determined by liquid phase tandem mass spectrometry, and the levels of vitamins A, D, and E in each age group were analyzed. Results There were 2 151 children for health examination and the average serum vitamin A level was (0.32±0.08) mg/L, where the vitamin A level in the ≤1-year-old group was the lowest at (0.29±0.075) mg/L. The vitamin A detection rate was 37.09% in all children, and was the highest at 54.19% in the ≤1-year-old group. The average serum 25(OH)D level was (34.24±9.31) μg/L, and was the lowest at (25.58±8.67) μg/L in the >6-year-old group. The detection rate of moderate and low level 25(OH)D was 33.56% (722/2 151) in all subjects, and was the highest at 77.89% in the >6-year-old group. The average serum vitamin E level was (10.69±3.57) mg/L in all children, and was the lowest at (8.59±1.96) mg/L in the >6-year-old group. The detection rate of moderate and low level vitamin E was 5.57% (120/2 151) among all subjects, and was the highest at 20% in the > 6-year-old group. The levels of serum 25(OH)D and vitamin E in boys were lower than those in girls. The level of serum 25(OH)D in 6-year-< age ≤ 14-year-old boy group was lower than that of girl group (P=0.043). The level of serum vitamin E in the ≤ 1-year-old boy group and the 1-year-old Conclusions The vitamin A level in the ≤1-year-old group is the lowest. The levels of 25(OH)D and vitamin E in children gradually decrease as the increase of age.

       

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