[1]王子宏.中性粒细胞/白蛋白比值对脓毒症患儿病情严重度及死亡风险的评估[J].徐州医科大学学报,2020,40(09):695-698.
 Evaluation of neutrophil / albumin ratio on the severity of sepsis and the risk of death in children[J].Journal of Xuzhou Medical University,2020,40(09):695-698.
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中性粒细胞/白蛋白比值对脓毒症患儿病情严重度及死亡风险的评估()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年09期
页码:
695-698
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
Evaluation of neutrophil / albumin ratio on the severity of sepsis and the risk of death in children
作者:
王子宏
文献标志码:
A
摘要:
目的: 探讨中性粒细胞/白蛋白比值与脓毒症患儿病情严重程度的相关性及对死亡风险的预测价值。方法: 收集本院收治的325例脓毒症患儿,根据发病后28d的生存情况分为存活组296例、死亡组29例。存活组患儿根据危重评分(PCIS)分为极危重组(36例),危重组(217例),非危重组(43例)。比较不同组间患儿中性粒细胞、白蛋白、中性粒细胞/白蛋白比值(NAR)间的差异,采用受试者工作特性曲线(ROC曲线)分析NAR对脓毒症患儿死亡风险的预测价值。结果: 脓毒症极危重组中性粒细胞计数、白蛋白、NAR值高于危重组及非危重组患儿,其中死亡组患儿上述指标水平进一步高于存活组患儿。ROC曲线显示,NAR水平为0.45时,曲线下面积为0.93,95%CI为0.86~0.99,灵敏度、特异度分别为90.91%、91.67%,约登指数最大0.83。存活组与死亡组患儿NAR值差异P<0.001,具有统计学意义。结论:NAR水平可较好反映脓毒症患儿的病情严重度,且有预测其死亡风险的价值。
Abstract:
ob<x>jective To investigate the correlation between neutrophil / albumin ratio and the severity of sepsis and the predictive value of death risk. Methods from January 2017 to October 2019, 325 children with sepsis were collected from the Anhui Huaibei maternal and child health care hospital. According to the survival conditions 28 days after the onset of sepsis, they were divided into two groups: the survival group 296 cases and the death group 29 cases. According to the PCIs, the survival group was divided into three groups: critical recombination (36 cases), critical recombination (217 cases) and noncritical recombination (43 cases). The differences of neutrophil, albumin and NAR among different groups were compared. The ROC curve was used to analyze the predictive value of NAR on the risk of death in children with sepsis. Results the number of neutrophils, albumin and NAR in sepsis were higher than those in critical and noncritical patients, and the above indexes in death group were higher than those in survival group. ROC curve showed that when NAR level was 0.45, the area under the curve was 0.93, 95% CI was 0.86-0.99, the sensitivity and specificity were 90.91% and 91.67%, respectively, and the maximum Jordan index was 0.83. The difference of NAR between the survival group and the death group was statistically significant (P < 0.001). Conclusion the level of NAR can ob<x>jectively reflect the severity of sepsis, and has a positive role in predicting the risk of death in sepsis
更新日期/Last Update: 2020-10-12