Abstract: ob＜x＞jective To evaluate the therapeutic effect of laparoscopic total hysterectomy combined with hysterosacral ligament shortening in treatment of uterine prolapse patients of perimenopausal period. Methods 30 perimenopausal period patients aged 40 to 60 with uterine prolapse underwent laparoscopic total hysterectomy combined with hysterosacral ligament shortening from January 2017 to December 2019 in Affiliated Hospital of Xuzhou Medical University.Pre and postoperative symptoms,pelvic organ prolapse quantitive examination (POP-Q),the MOS item short from health survey（SF-36），pelvic floor distress inventory-short form 20（PFDI-20）and pelvic organ prolapse /incontinence sexual function questionnaire 31(PISQ-31)measurements were used to assess quality of life and sexual life satisfaction.Results The POP-Q were better 6 months postoperatively than preoperative except total vaginal length(TVL).The difference were statistically significant（P＜0.05）.The SF-36 scores,PFDI-20 scores and PISQ-12 scores were better 6 months postoperatively than preoperative.The difference were statistically significant（P＜0.05）.Conclusions The therapeutic effect of laparoscopic total hysterectomy combined with hysterosacral ligament shortening in treatment of uterine prolapse patients of perimenopausal period was significant.HUS improved quality of life and sexual life satisfaction,which is worthy of clinical application and promotion.