[1]魏晓强,刘丽丽,孙贤华,等.Periostin和Ki67在宫颈癌中的表达及其与预后的关系[J].徐州医科大学学报,2022,42(03):225-230.[doi:10.3969/j.issn.2096-3882.2022.03.013]
　ex＜x＞pressions of Periostin and Ki67 and their relationship s with Prognostic Significance in cervical carcinoma[J].Journal of Xuzhou Medical University,2022,42(03):225-230.[doi:10.3969/j.issn.2096-3882.2022.03.013]
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Periostin和Ki67在宫颈癌中的表达及其与预后的关系()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
42
期数:
2022年03期
页码:
225-230
栏目:
出版日期:
2022-03-25

文章信息/Info

Title:
ex＜x＞pressions of Periostin and Ki67 and their relationship s with Prognostic Significance in cervical carcinoma
作者:
魏晓强1; 刘丽丽2; 孙贤华3; 杨绍文4*
1. 青岛市妇女儿童医院妇科中心，山东青岛266021；2. 青岛市中心医院病理科，山东青岛266021；3. 青岛市妇女儿童医院生殖科；4. 青岛市中心医院妇科
关键词:
Periostin; Ki67; 宫颈癌; 免疫组织化学; 预后
分类号:
R711.74
DOI:
10.3969/j.issn.2096-3882.2022.03.013
文献标志码:
A
摘要:
目的 研究Periostin和Ki67在宫颈癌中的表达，探讨两者分别与宫颈癌患者临床病理特征的关系，并分析可能影响宫颈癌患者预后的危险因素。方法 选取86例宫颈癌、30例正常宫颈组织，免疫组织化学SP法检测其中Periostin和Ki67蛋白的表达，分析二者的阳性表达与宫颈癌临床病理特征的关系、在宫颈癌组织中表达的相关性，并评估影响宫颈癌患者术后总生存时间的危险因素。结果 在86例宫颈癌组织中，Periostin和Ki67的阳性表达率较正常宫颈组织中均显著升高（P均<0.05），Periostin的阳性表达与临床分期、分化程度、脉管浸润及淋巴结转移有关（P均<0.05），Ki67的阳性表达与临床分期、淋巴结转移及分化程度有关（P均<0.05），两者在宫颈癌中的表达呈正相关关系（γ=0.319，P=0.003）。Periostin阳性的宫颈癌患者的总生存期显著降低（41.037个月 vs 63.67 2个月，Log-rank检验χ2=15.892，P=0.000），Periostin阳性表达为影响宫颈癌患者术后总生存期的独立危险因素（HR=3.916, 95%CI: 1.022-15.006, P=0.046<0.05）。结论 Periostin和Ki67在宫颈癌中的异常表达可能协同促进宫颈癌细胞的浸润及转移。Periostin阳性表达可能提示宫颈癌预后不良。
Abstract:
【ob＜x＞jective】 To analyze the ex＜x＞pressions of Periostin and Ki67 in cervical carcinoma , then evaluate the relationship between the positive ex＜x＞pressions of the two indicators and the clinical pathologic features , and prognostic analysis . 【Methods】 Immunohistochemistry was used to detect the ex＜x＞pression of Periostin and Ki67 in 86 cases of cervical carcinoma , 30 cases of normal cervical tissues. The relationships between the positive ex＜x＞pressions of Periostin and Ki67 and the clinical pathologic features in cervical carcinoma were analyzed . Then to assess the correlation between the two indicators and the risk factors affecting the overall survival time after surgery in patients with cervical ca rcinoma. 【Results】In 86 cervical carcinoma tissues , the positive rates of Periostin and Ki67 were significantly higher than those in normal cervical tissues（P all <0.05）. The positive ex＜x＞pressions of Periostin w ere correlated to clinical stage, tumor differentiation, vascular invasion and lymph node me＜x＞tastasis (P all <0.05) . Similarly, the positive ex＜x＞pressions of Ki67 were correlated to clinical stage, tumor differentiation, and lymph node me＜x＞tastasis(P all <0.05) , and there was a positive correlation between the two indexes in 86 cases of cervical carcinoma (γ=0.319，P=0.003) . The overall survival time was significantly lower in patients with Periostin positive cervical carcinoma ( 41.037 months vs 63.672 months ，Log-rank test χ2=15.892，P=0.000) , and the positive ex＜x＞pression of Periostin was an independent prognostic factor for overall survival in patients with cervical carcinoma (HR 3.916,95% CI: 1.022-15.006, P 0.046-0.05) . 【Conclusions】: The high ex＜x＞pressions of Periostin and Ki67 may synergistically participate in the malignant progression of cervical carcinoma. The positive ex＜x＞pression of Periostin may indicate a poor prognosis in cervical carcinoma.

相似文献/References:

[1]严专、李慧忠、许铁、刘林.负载gp96-Ki67 280-288复合物的树突状组胞疫苗对骨肉瘤的抗肿瘤效应体内实验研究[J].徐州医科大学学报,2015,35(06):402.
　[J].Journal of Xuzhou Medical University,2015,35(03):402.

备注/Memo

备注/Memo:
基金项目：青岛市科技局基金（18-2-2-78-JCH）*通信作者,E-mail：yangshaowen1028@126.com
更新日期/Last Update: 2022-05-09