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    贾元华, 张婷, 马竹生, 丁延超, 胡昕. 尿KIM-1及Netrin-1水平与慢性乙肝患者药源性肾损伤的相关性分析[J]. 徐州医科大学学报, 2022, 42(6): 451-454. DOI: 10.3969/j.issn.2096-3882.2022.06.012
    引用本文: 贾元华, 张婷, 马竹生, 丁延超, 胡昕. 尿KIM-1及Netrin-1水平与慢性乙肝患者药源性肾损伤的相关性分析[J]. 徐州医科大学学报, 2022, 42(6): 451-454. DOI: 10.3969/j.issn.2096-3882.2022.06.012
    Relationship analysis between urinary KIM-1, Netrin-1 and drug-induced renal dysfunction in chronic hepatitis B[J]. Journal of Xuzhou Medical University, 2022, 42(6): 451-454. DOI: 10.3969/j.issn.2096-3882.2022.06.012
    Citation: Relationship analysis between urinary KIM-1, Netrin-1 and drug-induced renal dysfunction in chronic hepatitis B[J]. Journal of Xuzhou Medical University, 2022, 42(6): 451-454. DOI: 10.3969/j.issn.2096-3882.2022.06.012

    尿KIM-1及Netrin-1水平与慢性乙肝患者药源性肾损伤的相关性分析

    Relationship analysis between urinary KIM-1, Netrin-1 and drug-induced renal dysfunction in chronic hepatitis B

    • 摘要: 目的 通过检测慢性乙型肝炎(慢性乙肝)患者药物治疗前后尿液中肾损伤分子-1(KIM-1)及神经导向因子-1(Netrin-1)的浓度,观察KIM-1及Netrin-1与慢性乙肝患者药源性肾损伤的相关性。方法 选取95例慢性乙肝患者,收集患者治疗前及治疗后12、24、36、48周时的空腹血及晨尿。通过酶联免疫吸附实验(ELISA)检测患者治疗前后尿液中KIM-1、Netrin-1表达量,利用常规生化试剂检测血清中HBV-DNA含量、ALT、肌酐(Cr)和估算的肾小球滤过率(eGFR)。结果 慢性乙肝患者经药物治疗后,患者体内的HBV-DNA含量显著减低,且ALT也显著降低。但是,长期使用药物治疗的慢性乙肝患者出现了药源性肾损伤的情况。通过ELISA实验检测,慢性乙肝患者经药物治疗后,尿液中KIM-1的含量较治疗前增高;同样,慢性乙肝患者经药物治疗后,尿液中Netrin-1的含量较治疗前增高。且尿KIM-1及Netrin-1均与Cr变化呈正相关,与eGFR的变化呈负相关。 结论 尿KIM-1及Netrin-1水平与慢性乙肝患者药源性肾损伤有显著的相关性。

       

      Abstract: ob<x>jective To detect the concentrations of KIM-1 and Netrin-1 in urine before and after drug treatment in chronic hepatitis B and observe correlation between KIM-1, Netrin-1 and drug-induced renal dysfuction in chronic hepatitis B. Methods Ninety-five patients with chronic hepatitis B were selected. Fasting blood and morning urine were collected before and after treatment at 12, 24, 36, and 48 weeks with drugs. The ex<x>pression of KIM-1 and Netrin-1 in the urine before and after treatment with drugs was detected by enzyme-li<x>nked immunosorbent assay (ELISA). The levels of HBV-DNA, ALT, creatinine (Cr) and estimated glomerular filtration rate (eGFR) in the serum were measured by using conventional biochemical reagents. Results After treatment with drugs, HBV-DNA content was significantly reduced in chronic hepatitis B, and ALT was also significantly reduced. However, chronic hepatitis B patients treated with drugs for a long time have caused drug-induced kidney injury. Through ELISA assay, the content of KIM-1 in urine of chronic hepatitis B after drug treatment was higher than that before treatment. Similarly, the content of Netrin-1 in urine of chronic hepatitis B after drug treatment was higher than that before treatment. Both urinary KIM-1 and Netrin-1 were positively correlated with changes in Cr and negatively correlated with changes in eGFR. Conclusion The levels of urinary KIM-1 and Netrin-1 are significantly associated with drug-induced renal dysfunction in chronic hepatitis B

       

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