[1]单思维,刘从兵,魏伟,等.甲状腺乳头状癌右侧喉返神经后方淋巴结转移的相关临床及超声特征评估[J].徐州医科大学学报,2021,41(03):200-204.[doi:10.3969/j.issn.2096-3882.2021.03.009]
 Evaluation of the clinical and ultrasound characteristics in the metastasis of lymphnode posterior to right recurrent laryngeal nerve in papillary thyroid carcinoma[J].Journal of Xuzhou Medical University,2021,41(03):200-204.[doi:10.3969/j.issn.2096-3882.2021.03.009]
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甲状腺乳头状癌右侧喉返神经后方淋巴结转移的相关临床及超声特征评估()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
41
期数:
2021年03期
页码:
200-204
栏目:
出版日期:
2021-03-25

文章信息/Info

Title:
Evaluation of the clinical and ultrasound characteristics in the metastasis of lymphnode posterior to right recurrent laryngeal nerve in papillary thyroid carcinoma
作者:
单思维12刘从兵2魏伟2袁方2胡春峰1*
1. 徐州医科大学附属医院影像科,江苏徐州221002;2.徐州医科大学附属宿迁医院超声科,江苏宿迁223800
关键词:
甲状腺乳头状癌右侧喉返神经后方淋巴结超声
分类号:
R44
DOI:
10.3969/j.issn.2096-3882.2021.03.009
文献标志码:
A
摘要:
目的评估甲状腺乳头状癌(PCT)患者右侧喉返神经后方淋巴结(lymph nodes posterior to right recurrent laryngeal nerve,LN-prRLN)转移的相关临床及超声特征危险因素。方法选取2016年1月—2019年12月于徐州医科大学附属宿迁人民医院手术治疗的右叶或双叶PTC患者,共158例,收集临床资料进行回顾性分析。根据术后病理LN-prRLN转移情况,将上述患者分为转移组(n=34)和对照组(n=124)。比较2组临床和声像图特征,分析与LN-prRLN转移有关的危险因素。结果本研究中PTC患者的LN-prRLN转移率为21.52%(34/158)。LN-prRLN转移组和对照组在年龄、肿瘤直径、包膜浸润、多灶性、喉前淋巴结及右侧喉返神经前方淋巴结(lymph nodes anterior to right recurrent laryngeal nerve,LN-arRLN)转移情况、超声显示肿瘤接触被膜方面比较差异均有统计学意义(P均<0.05)。多因素Logistic回归分析显示:右侧肿瘤直径、包膜浸润、喉前淋巴结及LN-arRLN转移情况均与LN-prRLN转移显著相关(P均<0.05)。ROC曲线显示预测LN-prRLN转移的右肿瘤直径的最佳截断值为12.7 mm,ROC曲线下面积(AUC)=0.72,灵敏度和特异度分别为74.3%和72.9%。结论PTC患者中,对于右侧叶肿瘤直径≥12.7 mm、包膜浸润、喉前淋巴结及LN-arRLN转移,应进行预防性LN-prRLN清扫。
Abstract:
ObjectiveTo evaluate the risk factors of clinical and ultrasound characteristics in the metastasis of lymph node posterior to right recurrent laryngeal nerve (LN-prRLN) in papillary thyroid carcinoma (PCT). MethodsA total of 158 PCT patients in the right lobe or double lobe who were operated in Suqian People′s Hospital Affiliated to Xuzhou Medical University from January 2016 to December 2019 were enrolled and their clinical data were retrospectively analyzed. According to the presence of LN-prRLN in postoperative pathological examination, the patients were divided into two groups: a metastasis group (n=34) and a control group (n=124). Both groups were compared for clinical and ultrasound characteristics. Logistic multivariable regression analysis was used to evaluate the risk factors related to LN-prRLN metastasis. ResultsIn the current study, the LN-prRLN metastasis rate in PCT patients was 21.52% (34/158). There were significant differences between the LN-prRLN metastasis group and the control group in age,tumor diameter, extracapsular invasion, multifocality, the metastasis of prelaryngeal lymph nodes and lymph nodes anterior to right recurrent laryngeal nerve (LN-arRLN), and ultrasound-determined tumor contact capsule (P< 0.05). Logistic multivariable regression analysis showed that tumor diameter in the right lobe, extracapsular invasion, the metastasis of prelaryngeal lymph nodes and LN-arRLN were significantly correlated with LN-prRLN metastasis (P< 0.05). The ROC curve showed that the optimal cut-off value of tumor diameter in the right lobe to predict the metastasis of LN-prRLN was 12.7 mm (AUC=0.72), with a sensitivity of 74.3%and a specificity of 72.9%. ConclusionsProphylactic lymph node dissection is suggested for PCT patients with a tumor diameter≥12.7 m min the right lobe, extracapsular invasion,the metastasis of prelaryngeal lymph nodes and LN-arRLN.

相似文献/References:

[1]王晖,李学庆,杨菊*,等.MIP-1α、MIP-1β在甲状腺乳头状癌中的表达及意义[J].徐州医科大学学报,2017,(11):725.
 WANG Hui,LI Xueqing,YANG Ju*,et al.The expressive and significance of MIP-lα/MIP-1β in papillary thyroid carcinoma[J].Journal of Xuzhou Medical University,2017,(03):725.

更新日期/Last Update: 2021-04-25