前白蛋白和血小板与广泛期小细胞肺癌预后的关系-《徐州医科大学学报》

文章信息/Info

Title:: Prognostic Value of Prealbumin and Platelet in Patients with S mall Cell Lung Cancer

摘要:: 目的通过分析治疗前前白蛋白、前白蛋白与广泛期小细胞肺癌（SCLC）的影响，探讨其在广泛期小细胞肺癌患者中的疗效预估和预后价值。方法本研究回顾性分析了2012年2月至2017年7月于徐州医科大学附属医院呼吸内科的广泛期116名SCLC患者，选择的患者均予标准EP方案化疗，未进行预防性颅脑放疗，死亡原因均为肿瘤进展导致。排除性别、年龄、合并症、ECOG评分的影响，用Kaplan-Meier方法和Cox比例风险模型分析患者治疗前前白蛋白、血小板和患者PFS、OS的关系。结果治疗前前白蛋白水平与患者PFS显著相关（P =0.013）,与患者OS显著相关（P =0.025）。治疗前血小板患者PFS无明显相关（P =0.093），但与患者OS显著相关(P =0.026)。结论：治疗前前白蛋白和血小板是影响广泛期小细胞肺癌预后和生存的因素。

Abstract:: ob＜x＞jective To analyze the data of prealbumin, platelet before treatment in extensive stage small cell lung cancer (SCLC) patients, and explore its prognostic value for patients with extensive-stage estimate small cell lung cancer. Methods This study?retrospectively analyzed 116 Patients with SCLC in the department?ofRespirtory Medicine in the Affiliated Hospital of Xuzhou Medical University from February 2012 ?to? July 201 7，who accepted the standardized EP chemotherapy. The reason of the death is the tumor. Excluding the impact of gender, age, comorbidities, ECOG score, the relationship between prealbumin and platelet ratio and patients’PFS and OS ?was?analyzed with Kaplan-Meier method and Cox?scale risk model. Results Prealbumin level before treatment in patients with PFS was significantly associated (P = 0.013), and significantly associated with the patients’ OS ( P = 0.025). Platelet before treatment was not significantly associated ( P = 0.093), but was significantly associated with the patients’ OS ( P = 0.026). Conclusion: The prealbumin and platelet before treatment was associated with the prognosis of extensive stage small cell lung cancer.