[1]余潜,曹平,瞿庄茵,等.汉防己甲素抑制大鼠肠道内P-糖蛋白功能调节药物吸收的机制研究[J].徐州医科大学学报,2020,40(11):786-789.[doi:10.3969/j.issn.2096-3882.2020.11.002]
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汉防己甲素抑制大鼠肠道内P-糖蛋白功能调节药物吸收的机制研究()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
40
期数:
2020年11期
页码:
786-789
栏目:
出版日期:
2020-11-25

文章信息/Info

Title:
Mechanism of tetrandrine inhibiting P-glycoprotein function and regulating drug absorption in rat intestine
作者:
余潜曹平瞿庄茵赵静高坤
南京医科大学附属南京医院(南京市第一医院)药学部,江苏 南京 210006;江苏省中医院肾内科,江苏 南京 210029
关键词:
汉防己甲素 P-糖蛋白 罗丹明123 体外扩散池法
DOI:
10.3969/j.issn.2096-3882.2020.11.002
文献标志码:
A
摘要:
目的 研究汉防己甲素(TET)通过调节P-糖蛋白(P-gp)功能影响肠道药物吸收的作用.方法 使用体外扩散池法(ussing chamber)测定评价P-gp底物罗丹明123(Rho123)在肠道内吸收方向和排出方向的透过量和透过系数(Papp),以及TET对Rho123和5(6)-羧基荧光素(CF)经离体大鼠肠黏膜透过性的影响.结果 TET可以促进Rho123的吸收,抑制其排出,且这一功能与细胞旁路转运无关.结论 TET可能具有抑制肠道内P-gp活性的作用.其可促进口服肿瘤药物的吸收并抑制多药耐药的发生,起到解毒增效的作用.
Abstract:
ob<x>jective: To investigate the effect of tetrandrine (TET) on intestinal absorption by regulating the function of P-glycoprotein (P-gp). Method: The effects of TET on the intestinal absorption of a P-glycoprotein substrate, rhodamine123 (Rho123) and 5(6)-carboxyfluorescein (CF), were examined by an in vitro diffusion chamber system. Results: It was shown that TET might have the activity of inhibiting P-gp function in the intestine. And the paracellular pathway were not the main reasons of enhanced absorptive transport of these P-gp substrates in the presence of TET. Conclusion: TET may inhibit the activity of P-gp in the intestine. TET can promote the absorption of oral tumor drugs and inhibit the occurrence of multidrug resistance.
更新日期/Last Update: 2020-12-15